ArticleArchives of disease in childhood2004
Intestinal permeability is increased in bronchial asthma.
Article in Archives of disease in childhood, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00852124 (Safety of VSL#3 for Adult Asthmatics), which is not on this map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety of VSL#3 for Adult Asthmatics
Who cites it
31 citing papers in PubMed, 78 citations in OpenAlex.
- Efficacy of probiotics and nutrients in functional gastrointestinal disorders: a preliminary clinical trial.Digestive diseases and sciences · 2006Trial
- Article
- Gut Mycobiome and Asthma.Journal of fungi (Basel, Switzerland) · 2024Review
- Association Between Gut and Nasal Microbiota and Allergic Rhinitis: A Systematic Review.Journal of asthma and allergy · 2024Review
- The Relationship Between Zonulin and Asthma: A Mouse Model Study.Journal of rhinology : official journal of the Korean Rhinologic Society · 2023Article
- Serum Zonulin Is a Biomarker for Severe Asthma.Allergy, asthma & immunology research · 2023Article
- Paracellular permeability and tight junction regulation in gut health and disease.Nature reviews. Gastroenterology & hepatology · 2023Review
- Granzymes, IL-16, and poly(ADP-ribose) polymerase 1 increase during wildfire smoke exposure.The journal of allergy and clinical immunology. Global · 2023Article
- Food, gut barrier dysfunction, and related diseases: A new target for future individualized disease prevention and management.Food science & nutrition · 2023Review
- The gut microbiota of people with asthma influences lung inflammation in gnotobiotic mice.iScience · 2023Article
- The Role of the Gallbladder, the Intestinal Barrier and the Gut Microbiota in the Development of Food Allergies and Other Disorders.International journal of molecular sciences · 2022Review
- Claudin-1 Mediated Tight Junction Dysfunction as a Contributor to Atopic March.Frontiers in immunology · 2022Article
- Asthma and obesity: endotoxin another insult to add to injury?Clinical science (London, England : 1979) · 2021Review
- Dietary Fibers: Effects, Underlying Mechanisms and Possible Role in Allergic Asthma Management.Nutrients · 2021Review
- Association between serum zonulin level and severity of house dust mite allergic asthma.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021Article
- Allergy-related diseases and early gut fungal and bacterial microbiota abundances in children.Clinical and translational allergy · 2021Article
- Maternal Allergy and the Presence of Nonhuman Proteinaceous Molecules in Human Milk.Nutrients · 2020Article
- From Osteoimmunology to Osteomicrobiology: How the Microbiota and the Immune System Regulate Bone.Calcified tissue international · 2018Review
- Bone Remodeling and the Microbiome.Cold Spring Harbor perspectives in medicine · 2018Review
- A Viewpoint on the Leaky Gut Syndrome to Treat Allergic Asthma: A Novel Opinion.Journal of evidence-based complementary & alternative medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreased intestinal permeability has been reported in one study of adult asthmatics.
aimTo determine whether children with asthma have altered intestinal permeability.
methodsThirty two asthmatic children, and 32 sex and age matched controls were recruited. The dual sugar (lactulose and mannitol) test was used to evaluate intestinal permeability, and the percentage of ingested lactulose (L) and mannitol (M) in the urine, and the L:M ratio were determined. All patients were skin prick tested for common aeroallergens, and specific IgE to some food items was determined.
resultsThe median value of L in asthmatic children (2.29, IQR 0.91-4.07) was significantly higher than that in controls (0.69, IQR 0.45-1.08), and that of M was almost similar. The ratio L:M was significantly higher in asthmatic children (0.20, IQR 0.11-0.40) than in controls (0.06, IQR 0.04-0.09). Intestinal permeability did not correlate with eczema, inhaled steroids, positive skin prick test to aeroallergens, or severity of asthma.
conclusionsIntestinal permeability is increased in children with asthma, suggesting that the whole mucosal system may be affected.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.