ArticleMolecular and cellular biochemistry
The velocity of calcium waves is expected to depend non-monotoneously on the density of the calcium release units.
Article in Molecular and cellular biochemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- The Plastic Glial-Synaptic Dynamics within the Neuropil: A Self-Organizing System Composed of Polyelectrolytes in Phase Transition.Neural plasticity · 2016Review
- Relevance of excitable media theory and retinal spreading depression experiments in preclinical pharmacological research.Current neuropharmacology · 2014Article
- Disposition of calcium release units in agarose gel for an optimal propagation of Ca2+ signals.Biophysical journal · 2004Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper we develop a reaction-diffusion system describing the calcium dynamics in an agarose gel system with resuspended vesicles from the sarcoplasmic reticulum (SR vesicles). We focus on a simple model: compared with living cells (e.g. cardiac myocytes) an important property of the agarose gel system is the absence of the sarcolemma and the spatial separation of the calcium release units (CRUs). Our model includes the kinetics of ryanodine sensitive receptors (RyRs), the activity of the SERCA pumps and the diffusion of free calcium. We describe numerical simulations which show a biphasic relationship between the density of the CRUs and the propagation velocity of spreading waves. The non-monotony can be explained by changes in the amplitude of the local calcium concentration. We formulate implications for the in vitro system which could be verified in future experiments.
Indexed as
Identifiers
14977197What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.