ReviewMolecular and cellular biochemistry
Organization and regulation of the cytosolic NADH metabolism in the yeast Saccharomyces cerevisiae.
Review in Molecular and cellular biochemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Characteristics ofJournal of oral microbiology · 2026Article
- Impact of CRISPRi-Mediated Titration ofACS synthetic biology · 2025Article
- Glycerol Biosynthesis Pathways from Starch EndowInternational journal of molecular sciences · 2025Article
- Exploring fermentative metabolic response to varying exogenous supplies of redox cofactor precursors in selected wine yeast species.FEMS yeast research · 2024Article
- Cofactor Engineering for Efficient Production of α-Farnesene by Rational Modification of NADPH and ATP Regeneration Pathway inInternational journal of molecular sciences · 2023Article
- The same genetic regulation strategy produces inconsistent effects in different Saccharomyces cerevisiae strains for 2-phenylethanol production.Applied microbiology and biotechnology · 2022Article
- Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways.Metabolites · 2022Review
- Engineering Saccharomyces cerevisiae for the production and secretion of Affibody molecules.Microbial cell factories · 2022Article
- Respiratory reoxidation of NADH is a key contributor to high oxygen requirements of oxygen-limited cultures of Ogataea parapolymorpha.FEMS yeast research · 2022Article
- Thriving in Oxygen While Preventing ROS Overproduction: No Two Systems Are Created Equal.Frontiers in physiology · 2022Review
- Deciphering the mechanism by which the yeast Phaffia rhodozyma responds adaptively to environmental, nutritional, and genetic cues.Journal of industrial microbiology & biotechnology · 2021Review
- In-depth understanding of molecular mechanisms of aldehyde toxicity to engineer robust Saccharomyces cerevisiae.Applied microbiology and biotechnology · 2021Review
- L-asparaginase Production byFrontiers in bioengineering and biotechnology · 2020Article
- Mitochondria-Associated Membranes (MAMs) are involved in Bax mitochondrial localization and cytochrome c release.Microbial cell (Graz, Austria) · 2019Article
- Elucidating redox balance shift in Scheffersomyces stipitis' fermentative metabolism using a modified genome-scale metabolic model.Microbial cell factories · 2018Article
- Reconstruction of metabolic module with improved promoter strength increases the productivity of 2-phenylethanol in Saccharomyces cerevisiae.Microbial cell factories · 2018Article
- A common mechanism explains the induction of aerobic fermentation and adaptive antioxidant response in Phaffia rhodozyma.Microbial cell factories · 2018Article
- Conditions promoting effective very high gravity sugarcane juice fermentation.Biotechnology for biofuels · 2018Article
- Altered Expression of Mitochondrial NADFrontiers in genetics · 2018Article
- Glycerol-3-Phosphate Shuttle Is Involved in Development and Virulence in the Rice Blast FungusFrontiers in plant science · 2018Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keeping a cytosolic redox balance is a prerequisite for living cells in order to maintain a metabolic activity and enable growth. During growth of Saccharomyces cerevisiae, an excess of NADH is generated in the cytosol. Aerobically, it has been shown that the external NADH dehydrogenase, Nde1p and Nde2p, as well as the glycerol-3-phosphate dehydrogenase shuttle, comprising the cytoplasmic glycerol-3-phosphate dehydrogenase, Gpdlp, and the mitochondrial glycerol-3-phosphate dehydrogenase, Gut2p, are the most important mechanisms for mitochondrial oxidation of cytosolic NADH. In this review we summarize the recent results showing (i) the contribution of each of the mechanisms involved in mitochondrial oxidation of the cytosolic NADH, under different physiological situations; (ii) the kinetic and structural properties of these metabolic pathways in order to channel NADH from cytosolic dehydrogenases to the inner mitochondrial membrane and (iii) the organization in supramolecular complexes and, the peculiar ensuing kinetic regulation of some of the enzymes (i.e. Gut2p inhibition by external NADH dehydrogenase activity) leading to a highly integrated functioning of enzymes having a similar physiological function. The cell physiological consequences of such an organized and regulated network are discussed.
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