ArticleProceedings of the National Academy of Sciences of the United States of America2004
K channel gating by an affinity-switching selectivity filter.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Gating crosstalk in potassium channels.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The nonconducting W434F mutant adopts upon membrane depolarization an inactivated-like state that differs from wild-type Shaker-IR potassium channels.Science advances · 2022Article
- TRP ion channels: Proteins with conformational flexibility.Channels (Austin, Tex.) · 2019Review
- Gating the glutamate gate of CLC-2 chloride channel by pore occupancy.The Journal of general physiology · 2016Article
- Pore waters regulate ion permeation in a calcium release-activated calcium channel.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- A novel current pathway parallel to the central pore in a mutant voltage-gated potassium channel.The Journal of biological chemistry · 2011Article
- A permeation theory for single-file ion channels: one- and two-step models.The Journal of chemical physics · 2011Article
- Separation of heteromeric potassium channel Kcv towards probing subunit composition-regulated ion permeation and gating.FEBS letters · 2010Article
- Fast and slow gating are inherent properties of the pore module of the K+ channel Kcv.The Journal of general physiology · 2009Article
- Cooperative transition between open and closed conformations in potassium channels.PLoS computational biology · 2008Article
- Stability of the Shab K+ channel conductance in 0 K+ solutions: the role of the membrane potential.Biophysical journal · 2007Article
- Conformational dynamics of the KcsA potassium channel governs gating properties.Nature structural & molecular biology · 2007Article
- The protonation state of the Glu-71/Asp-80 residues in the KcsA potassium channel: a first-principles QM/MM molecular dynamics study.Biophysical journal · 2007Article
- Ion conductance vs. pore gating and selectivity in KcsA channel: modeling achievements and perspectives.Journal of molecular modeling · 2007Article
- Control of single channel conductance in the outer vestibule of the Kv2.1 potassium channel.The Journal of general physiology · 2006Article
- Allosteric effects of external K+ ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K+ channel.Pflugers Archiv : European journal of physiology · 2006Article
- Elongation of outer transmembrane domain alters function of miniature K+ channel Kcv.The Journal of membrane biology · 2006Article
- K channel subconductance levels result from heteromeric pore conformations.The Journal of general physiology · 2005Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
A universal property of ion channels is their ability to alternate stochastically between two permeation states, open and closed. This behavior is thought to be controlled by a steric "gate", a structure that physically impedes ion flow in the closed state and moves out of the way during channel opening. Experiments employing macroscopic currents in the Shaker K channel have suggested a cytoplasmic localization for the gate. Crystallographic structures of the KcsA K channel indeed reveal a cytoplasmic constriction, implying that the gate and selectivity filter are localized to opposite ends of the permeation pathway. However, analysis of K channel subconductance behavior has suggested a strict coupling between channel opening (gating) and permeation. The idea that the selectivity filter is the gate was therefore investigated by using Monte Carlo simulations. Gating is accomplished by allowing the filter to alternate stochastically between two conformations: a high-affinity state, which selectively binds K ions (but not Na ions) and traps them, and a completely nonselective, low-affinity state, which allows both Na and K ions to permeate. The results of these simulations indicate that affinity switching not only endows the selectivity filter with gating abilities, it also allows efficient permeation without jeopardizing ion selectivity. In this model, permeation and gating result from the same process.
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