SynthesisBMJ (Clinical research ed.)2004
Systematic review of prevalence of aspirin induced asthma and its implications for clinical practice.
Synthesis in BMJ (Clinical research ed.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 4 syntheses or guidelines pooled it, 451 citations in OpenAlex.
- Diagnosis and Management of Hypersensitivity to Antiplatelet Drugs: EAACI Position Paper.Allergy · 2025Pooled it
- Multiple sclerosis and the incidence of venous thromboembolism: a systematic review and meta-analysis.Journal of thrombosis and thrombolysis · 2023Pooled it
- Urinary Leukotriene E4 as a Biomarker in NSAID-Exacerbated Respiratory Disease (N-ERD): a Systematic Review and Meta-analysis.Current allergy and asthma reports · 2022Pooled it
- Paracetamol (acetaminophen) use in infants and children was never shown to be safe for neurodevelopment: a systematic review with citation tracking.European journal of pediatrics · 2022Pooled it
- Diagnostic Role of Aspirin Challenge in NSAID-Exacerbated Respiratory Disease: A Prospective Single-Center Study in China.Allergy, asthma & immunology research · 2026Article
- Chinese Guidelines for Diagnosis and Treatment of Chronic Rhinosinusitis (2024).World journal of otorhinolaryngology - head and neck surgery · 2026Article
- Successful Management of Aspirin Intolerance After Ad Hoc PCI: A Case Report and a Developed Algorithm.Clinical case reports · 2026Article
- IL-5/IL-5R blockade enables safe non-steroidal anti-inflammatory agent reintroduction in non-steroidal anti-inflammatory exacerbated respiratory disease.Frontiers in immunology · 2026Article
- Position Statement on Antiplatelet Therapy for East Asians With Coronary Artery Disease: 2025 Update.JACC. Asia · 2025Review
- Aspirin Hypersensitivity in Patients with Coronary Artery Disease: An Updated Review and Practical Recommendations.Biomolecules · 2024Review
- Review
- Navigating Aspirin Hypersensitivity in Patients Undergoing Percutaneous Coronary Intervention.Journal of medical cases · 2024Article
- [Expert consensus on the diagnosis and treatment of respiratory diseases exacerbated by nonsteroidal anti-inflammatory drugs （2024, Chengdu）].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Article
- Analysis of Allergy and Hypersensitivity Reactions to COVID-19 Vaccines According to the EudraVigilance Database.Life (Basel, Switzerland) · 2024Article
- An Update on Nonsteroidal Anti-Inflammatory Drug-Induced Urticaria.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Risk factors of NSAID-exacerbated respiratory disease: A population-based study.Clinical and translational allergy · 2023Article
- Coronary Artery Disease and Aspirin Intolerance: Background and Insights on Current Management.Cardiology and therapy · 2022Review
- The Utility of Nasal Challenges to Phenotype Asthma Patients.International journal of molecular sciences · 2022Review
- NSAID Hypersensitivity in the Pediatric Population: Classification and Diagnostic Strategies.Journal of asthma and allergy · 2022Review
- Non-steroidal anti-inflammatory drug-induced anaphylaxis infrequent in 388 patients with mastocytosis: A two-center retrospective cohort study.Frontiers in allergy · 2022Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo reassess the prevalence of aspirin induced asthma and other issues related to the syndrome. DATA SOURCES: Biosis, SciSearch (1990 to March 2002), Embase (1974 to March 2002), Medline (1966 to March 2002), Toxline, Derwent Drug File (1964 to March 2002), Conference Papers Index and Inside Conferences, Int'l Pharmaceutical Abstracts, Pharma-Online (1978 to March 2002). SELECTION CRITERIA: Study type, patient population, and outcome measures. Review was restricted to respiratory responses to analgesics available without prescription.
resultsThe prevalence of aspirin induced asthma was highest when determined by oral provocation testing (adults 21%, 95% confidence interval 14% to 29%; children 5%, 0% to 14%) than by verbal history (adults 3%, 2% to 4%; children 2%, 1% to 3%). Cross sensitivity to doses of over the counter non-steroidal anti-inflammatory drugs was present in most patients with aspirin induced asthma: ibuprofen, 98%; naproxen, 100%; and diclofenac, 93%. The incidence of cross sensitivity to paracetamol among such patients was only 7%.
conclusionsAspirin induced asthma in adults is more prevalent than previously suggested. When there is a clinical necessity to use aspirin or a non-steroidal anti-inflammatory drug and there is uncertainty about safety, oral provocation testing should be performed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.