SynthesisThe Cochrane database of systematic reviews2004
Thrombolysis for cerebral vein and dural sinus thrombosis.
Synthesis in The Cochrane database of systematic reviews, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01204333 (Thrombolysis or Anticoagulation for Cerebral Venous Thrombosis), which is not on this map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Thrombolysis or Anticoagulation for Cerebral Venous Thrombosis (TOACT)
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- Antiepileptic drugs for the primary and secondary prevention of seizures after intracranial venous thrombosis.The Cochrane database of systematic reviews · 2016Pooled it
- Guideline
- Effect of Endovascular Treatment With Medical Management vs Standard Care on Severe Cerebral Venous Thrombosis: The TO-ACT Randomized Clinical Trial.JAMA neurology · 2020Trial
- Management of pott's puffy tumor: a Delphi-method international clinical consensus statement.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Clinical outcomes of endovascular interventions for cerebral venous thrombosis in Japan: a nationwide retrospective study.Stroke and vascular neurology · 2025Article
- Sliding balloon-assisted thrombectomy combined with aspiration and intrasinus urokinase thrombolysis for the treatment of hemorrhagic cerebral venous sinus thrombosis: experience of 10 patients.Frontiers in neurology · 2025Article
- Article
- Prolonged Microcatheter-Based Local Thrombolytic Infusion as a Salvage Treatment After Failed Endovascular Treatment for Cerebral Venous Thrombosis: A Multicenter Experience.Neurocritical care · 2018Article
- Endovascular suction thrombectomy for severe cerebral venous sinus thrombosis: A report of two cases.Journal of Taibah University Medical Sciences · 2018Article
- Cerebral venous thrombosis.Nature reviews. Neurology · 2017Review
- Outcome of a cohort of severe cerebral venous thrombosis in intensive care.Annals of intensive care · 2016Article
- Guidance for the management of venous thrombosis in unusual sites.Journal of thrombosis and thrombolysis · 2016Review
- Endovascular treatments for cerebral venous sinus thrombosis.Journal of thrombosis and thrombolysis · 2015Review
- Cerebral venous thrombosis: a Moroccan retrospective study of 30 cases.The Pan African medical journal · 2014Article
- Intracranial Hypertension due to Cerebral Venous Sinus Thrombosis following Head Trauma: A Report of Two Cases.Case reports in neurology · 2013Article
- Prolonged direct catheter thrombolysis of cerebral venous sinus thrombosis in children: a case series.Journal of child neurology · 2012Article
- Decompressive hemicraniectomy followed by endovascular thrombosuction in a patient with cerebral venous thrombosis.Journal of neurology · 2012Article
- Cerebral venous sinus thrombosis associated with bulimia nervosa.BMJ case reports · 2011Review
- A case of worsening deep cerebral venous sinus thrombosis managed by intrasinus thrombolysis.Case reports in neurological medicine · 2011Article
- Cerebral venous thrombosis in the mediterranean area in children.Mediterranean journal of hematology and infectious diseases · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTreatment of cerebral sinus thrombosis with thrombolytics has been reported in cases with a deteriorating clinical course despite anticoagulant therapy. The rationale of this treatment is to promote rapid recanalisation of the occluded sinus.
objectivesTo review the available evidence on the efficacy and safety of thrombolysis in confirmed cerebral sinus thrombosis. SEARCH STRATEGY: We searched the Cochrane Stroke Group trials register (March 2003), the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 1, 2003), MEDLINE (1966 to March 2003), EMBASE (1980 to March 2003), and reference lists of all relevant publications. SELECTION CRITERIA: We aimed to analyse separately unconfounded randomised controlled trials comparing thrombolytic agent with placebo, or thrombolytic agent with antithrombotic therapy, or thrombolytic agent and antithrombotic with antithrombotic alone, in patients with dural sinus thrombosis (confirmed by MR venography, intra-arterial venography or CT venography). DATA COLLECTION AND ANALYSIS: Two groups of reviewers independently applied the inclusion criteria. MAIN
resultsNo randomised controlled trials were found. REVIEWER'S
conclusionsThere is currently no available evidence from randomised controlled trials regarding the efficacy or safety of thrombolytic therapy in dural sinus thrombosis. A randomised controlled trial is justified to test this therapy especially in patients predicted to have a poor prognosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.