ReviewJournal of mammary gland biology and neoplasia2000
Genetically engineered mouse models of mammary intraepithelial neoplasia.
Review in Journal of mammary gland biology and neoplasia, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 70 citations in OpenAlex.
- Article
- HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase.Molecular cancer research : MCR · 2021Article
- Discriminating the earliest stages of mammary carcinoma using myoepithelial and proliferative markers.PloS one · 2018Article
- Article
- Systematic evaluation of skin and adnexa in mutant laboratory mice.Current protocols in mouse biology · 2014Article
- The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis.Oncotarget · 2014Article
- Training pathologists in mouse pathology.Veterinary pathology · 2012Article
- Real-time intravital imaging of cancer models.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2011Review
- RUNX1 and its understudied role in breast cancer.Cell cycle (Georgetown, Tex.) · 2011Article
- A compendium of the mouse mammary tumor biologist: from the initial observations in the house mouse to the development of genetically engineered mice.Cold Spring Harbor perspectives in biology · 2011Article
- Identification of early molecular markers for breast cancer.Molecular cancer · 2011Article
- Estrogen-dependent and estrogen-independent mechanisms contribute to AIB1-mediated tumor formation.Cancer research · 2010Article
- Spontaneous feline mammary intraepithelial lesions as a model for human estrogen receptor- and progesterone receptor-negative breast lesions.BMC cancer · 2010Article
- A mouse by any other name ...The Journal of investigative dermatology · 2009Article
- Genetic mechanisms in Apc-mediated mammary tumorigenesis.PLoS genetics · 2009Article
- "It is the antigen(s), stupid" and other lessons from over a decade of vaccitherapy of human cancer.Seminars in immunology · 2008Review
- The relevance of mouse models to understanding the development and progression of human breast cancer.Journal of mammary gland biology and neoplasia · 2008Review
- Premalignant and malignant mammary lesions induced by MMTV and chemical carcinogens.Journal of mammary gland biology and neoplasia · 2008Review
- Mus tales: a hands-on view.Journal of mammary gland biology and neoplasia · 2008Review
- Integrating mouse anatomy and pathology ontologies into a phenotyping database: tools for data capture and training.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Foci of atypical mammary epithelium have been associated with breast cancer in many species including mouse and man. The advent of targeted genomics has led to the creation of numerous genetically engineered mice (GEM) which display focal atypical lesions associated with mammary cancer. Some early lesions in GEM have a remarkable morphological similarity to pre-cancers in humans. While the malignant potential of atypical foci have been thoroughly documented in the non-GEM by tissue transplantation, a review of the literature reveals that precursor lesions in GEM remain incompletely described and only partially documented. Their validation as appropriate models of human breast preneoplasia awaits classical transplantation studies. Here, we review the literature characterizing early lesions of GEM models of mammary cancer, discuss the principles of the Focality, Atypia, and Association and present an introduction of mammary transplantation for model Validation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.