ReviewJournal of mammary gland biology and neoplasia2000
The preneoplastic phenotype in murine mammary tumorigenesis.
Review in Journal of mammary gland biology and neoplasia, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Nonlinear progression during the occult transition establishes cancer lethality.Disease models & mechanisms · 2025Article
- A novel and cost-effectiveBiology open · 2020Article
- Modeling Human Ductal Carcinoma In Situ in the Mouse.Journal of mammary gland biology and neoplasia · 2018Review
- Mouse models for radiation-induced cancers.Mutagenesis · 2016Review
- Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland.PLoS genetics · 2014Article
- Does cancer start in the womb? altered mammary gland development and predisposition to breast cancer due to in utero exposure to endocrine disruptors.Journal of mammary gland biology and neoplasia · 2013Review
- Mouse models for efficacy testing of agents against radiation carcinogenesis—a literature review.International journal of environmental research and public health · 2012Review
- A compendium of the mouse mammary tumor biologist: from the initial observations in the house mouse to the development of genetically engineered mice.Cold Spring Harbor perspectives in biology · 2011Article
- Aryl hydrocarbon receptor activation during pregnancy, and in adult nulliparous mice, delays the subsequent development of DMBA-induced mammary tumors.International journal of cancer · 2011Article
- Murine mammary epithelial stem cells: discovery, function, and current status.Cold Spring Harbor perspectives in biology · 2011Review
- Of mice and women: A short history of mouse mammary cancer research with an emphasis on the paradigms inspired by the transplantation method.Cold Spring Harbor perspectives in biology · 2010Review
- A role for KAI1 in promotion of cell proliferation and mammary gland hyperplasia by the gp78 ubiquitin ligase.The Journal of biological chemistry · 2010Article
- Common integration sites for MMTV in viral induced mouse mammary tumors.Journal of mammary gland biology and neoplasia · 2008Review
- Mus tales: a hands-on view.Journal of mammary gland biology and neoplasia · 2008Review
- Re-evaluation of mammary stem cell biology based on in vivo transplantation.Breast cancer research : BCR · 2008Article
- Stem cells and the mammary microenvironment.Breast disease · 2008Article
- Multistep mouse mammary tumorigenesis through pre-neoplasia to neoplasia and acquisition of metastatic potential.Medical molecular morphology · 2007Review
- Stem cells and mammary cancer in mice.Stem cell reviews · 2005Review
- Mammary epithelial stem cells: transplantation and self-renewal analysis.Cell proliferation · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Preneoplastic lesions in murine mammary tumorigenesis have been extensively investigated over the past 50 years. The two general types of lesion that have malignant potential are the alveolar hyperplasias represented by the classical hyperplastic alveolar nodule and the ductal hyperplasias. The former type of lesion is induced by viral, chemical and hormonal agents; the latter by chemical agents and specific genetic alterations. Individual animal models have been utilized to elucidate the basic biological properties of the lesions and some of the basic molecular alterations. The biological phenotype of the two types of lesions include immortalization and epithelial hyperplasia. The ductal hyperplasias are distinguished from the alveolar hyperplasias by their pattern of epithelial hyperplasia and their extent of aneuploidy. The molecular alterations underlying epithelial hyperplasia are numerous and dependent on the particular animal model. An important issue for future studies is how faithfully any of these models mimic human premalignant progression. A minimal set of criteria is proposed that includes morphological progression, hormone dependence and genetic instability. It is likely that hyperplasias from a specific mouse model will represent a subset of the lesions found in human disease. Analogous hyperplasias from several defined genetic models, adequately characterized at the biological and molecular levels, would provide appropriate models for testing chemopreventive agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.