ReviewJournal of mammary gland biology and neoplasia2003
Expression profiling of human breast cancers and gene regulation by progesterone receptors.
Review in Journal of mammary gland biology and neoplasia, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 64 citations in OpenAlex.
- Reevaluating the Role of Progesterone in Ovarian Cancer: Is Progesterone Always Protective?Endocrine reviews · 2023Article
- Progesterone Receptors Promote Quiescence and Ovarian Cancer Cell Phenotypes via DREAM in p53-Mutant Fallopian Tube Models.The Journal of clinical endocrinology and metabolism · 2021Article
- Progesterone promotes immunomodulation and tumor development in the murine mammary gland.Journal for immunotherapy of cancer · 2021Article
- Breast Cancer Risk with Progestin Subdermal Implants: A Challenge in Patients Counseling.Frontiers in endocrinology · 2021Review
- Mitochondrial determinants of cancer health disparities.Seminars in cancer biology · 2017Review
- A truncated progesterone receptor (PR-M) localizes to the mitochondrion and controls cellular respiration.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Patient-derived luminal breast cancer xenografts retain hormone receptor heterogeneity and help define unique estrogen-dependent gene signatures.Breast cancer research and treatment · 2012Article
- The biology of progesterone receptor in the normal mammary gland and in breast cancer.Molecular and cellular endocrinology · 2012Review
- Role of phosphorylation in progesterone receptor signaling and specificity.Molecular and cellular endocrinology · 2012Review
- Article
- A steroid-conjugated magnetic resonance probe enhances contrast in progesterone receptor expressing organs and tumors in vivo.Molecular pharmaceutics · 2011Article
- Progesterone receptor isoform-specific promoter methylation: association of PRA promoter methylation with worse outcome in breast cancer patients.Clinical cancer research : an official journal of the American Association for Cancer Research · 2011Article
- Progesterone receptor action: defining a role in breast cancer.Expert review of endocrinology & metabolism · 2011Article
- Altered retinoid uptake and action contributes to cell survival in endometriosis.The Journal of clinical endocrinology and metabolism · 2010Article
- Progesterone receptor A-regulated gene expression in mammary organoid cultures.The Journal of steroid biochemistry and molecular biology · 2009Article
- Strain-specific differences in the mechanisms of progesterone regulation of murine mammary gland development.Endocrinology · 2009Article
- Review
- Epigenetic repression of the estrogen-regulated Homeobox B13 gene in breast cancer.Carcinogenesis · 2008Article
- Progesterone and breast cancer.Women's health (London, England) · 2008Review
- Progesterone receptor isoform functions in normal breast development and breast cancer.Critical reviews in eukaryotic gene expression · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Even the first expression profiling studies of breast cancers have generated new insights. They suggest for example, that information about tumor aggressiveness, prognosis, metastatic potential, or treatment outcome is encoded in, and can be deduced from, the primary tumor. On the other hand no clinical genomic array data have yet been published that deal with hormonal aspects of breast tumorigenesis, tumor progression, or therapeutics. Rather, studies have focused on experimental model systems. We review below the currently published data on array profiling in clinical breast cancer, then describe our studies in breast cancer cell lines and xenograft models dealing with progesterone receptors (PRs) and the role of progesterone. We demonstrate that the two PR isoforms, PR-A and PR-B, have mostly nonoverlapping molecular signatures when liganded by progesterone, with PR-B the more active form. Additionally, we document the surprising finding that unliganded PRs can regulate gene transcription, with PR-A the more active form. In ovariectomized mice supplemented with estradiol but lacking measurable progesterone, PR-B-expressing tumors grow to twice the size of PR-A-expressing ones. We conclude that in breast cancers, PRs are more than simple markers of estrogen receptor function. Rather, presence of PRs and the ratio of the two isoforms directly influence tumor phenotype, even in the absence of ligand.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.