ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 115 citations in OpenAlex.
- Transfusion-related acute lung injury-associated HNA-3a antibodies recognize complex determinants on choline transporter-like protein 2.Transfusion · 2014Trial
- GENETIC DETERMINANTS OF THROMBOSIS.Transactions of the American Clinical and Climatological Association · 2024Article
- Lack of the human choline transporter-like protein SLC44A2 causes hearing impairment and a rare red blood phenotype.EMBO molecular medicine · 2023Article
- Transporter-Mediated Drug Delivery.Molecules (Basel, Switzerland) · 2023Review
- Platelet-Neutrophil Crosstalk in Thrombosis.International journal of molecular sciences · 2023Review
- A review of the auditory-gut-brain axis.Frontiers in neuroscience · 2023Review
- The Roles of Solute Carriers in Auditory Function.Frontiers in genetics · 2022Review
- Functional and Biochemical Consequences of Disease Variants in Neurotransmitter Transporters: A Special Emphasis on Folding and Trafficking Deficits.Pharmacology & therapeutics · 2021Review
- The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function.Nature communications · 2020Article
- SLC44A2 deficient mice have a reduced response in stenosis but not in hypercoagulability driven venous thrombosis.Journal of thrombosis and haemostasis : JTH · 2020Article
- Article
- Characterization of hemostasis in mice lacking the novel thrombosis susceptibility gene Slc44a2.Thrombosis research · 2018Article
- Molecular Genetics of the Human Neutrophil Antigens.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2018Review
- Molecular and Functional Characterization of Choline Transporter-Like Proteins in Esophageal Cancer Cells and Potential Therapeutic Targets.Biomolecules & therapeutics · 2018Article
- Autoimmune inner ear disease secondary to Hashimoto's thyroiditis: a case report.Journal of community hospital internal medicine perspectives · 2018Article
- SLC44A2 single nucleotide polymorphisms, isoforms, and expression: Association with severity of Meniere's disease?Genomics · 2016Article
- Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.Science translational medicine · 2016Article
- Pathophysiology of the cochlear intrastrial fluid-blood barrier (review).Hearing research · 2016Review
- Full-length nucleotide sequences of 30 common SLC44A2 alleles encoding human neutrophil antigen-3.Transfusion · 2016Article
- Hair Cell Loss, Spiral Ganglion Degeneration, and Progressive Sensorineural Hearing Loss in Mice with Targeted Deletion of Slc44a2/Ctl2.Journal of the Association for Research in Otolaryngology : JARO · 2015Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
Abstract
The Kresge Hearing Research Institute-3 (KHRI-3) antibody binds to a guinea pig inner ear supporting cell antigen (IESCA) and causes hearing loss. To gain insight into the mechanism of antibody-induced hearing loss, we used antibody immunoaffinity purification to isolate the IESCA, which was then sequenced by mass spectroscopy, revealing 10 guinea pig peptides identical to sequences in human choline transporter-like protein 2 (CTL2). Full-length CTL2 cDNA sequenced from guinea pig inner ear has 85.9% identity with the human cDNA. Consistent with its expression on the surface of supporting cells in the inner ear, CTL2 contains 10 predicted membrane-spanning regions with multiple N-glycosylation sites. The 68 and 72 kDa molecular forms of inner ear CTL2 are distinguished by sialic acid modification of the carbohydrate. The KHRI-3 antibody binds to an N-linked carbohydrate on CTL2 and presumably damages the organ of Corti by blocking the transporter function of this molecule. CTL2 mRNA and protein are abundantly expressed in human inner ear. Sera from patients with autoimmune hearing loss bind to guinea pig inner ear with the same pattern as CTL2 antibodies. Thus, CTL2 is a possible target of autoimmune hearing loss in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.