ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Decreased phosphorylation of NMDA receptor type 1 at serine 897 in brains of patients with Schizophrenia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 75 citations in OpenAlex.
- Effects of Augmenting N-Methyl-D-Aspartate Receptor Signaling on Working Memory and Experience-Dependent Plasticity in Schizophrenia: An Exploratory Study Using Acute d-cycloserine.Schizophrenia bulletin · 2017Trial
- PTMs: A Missing Piece for Schizophrenia Studies.Advances in experimental medicine and biology · 2022Article
- Investigating Post-translational Modifications in Neuropsychiatric Disease: The Next Frontier in Human Post-mortem Brain Research.Frontiers in molecular neuroscience · 2021Review
- Hispidulin attenuates the social withdrawal in isolated disrupted-in-schizophrenia-1 mutant and chronic phencyclidine-treated mice.British journal of pharmacology · 2020Article
- Synaptic Plasticity Shapes Brain Connectivity: Implications for Network Topology.International journal of molecular sciences · 2019Review
- Elevated serum anti-NMDA receptor antibody levels in first-episode patients with schizophrenia.Brain, behavior, and immunity · 2019Article
- Altered Expression of a Unique Set of Genes Reveals Complex Etiology of Schizophrenia.Frontiers in psychiatry · 2019Article
- Mapping the Consequences of Impaired Synaptic Plasticity in Schizophrenia through Development: An Integrative Model for Diverse Clinical Features.Trends in cognitive sciences · 2017Review
- Bridging the Gap between Genes and Language Deficits in Schizophrenia: An Oscillopathic Approach.Frontiers in human neuroscience · 2016Article
- DNA microarray unravels rapid changes in transcriptome of MK-801 treated rat brain.World journal of biological chemistry · 2015Article
- Peripheral adipose tissue insulin resistance alters lipid composition and function of hippocampal synapses.Journal of neurochemistry · 2015Article
- Postsynaptic density levels of the NMDA receptor NR1 subunit and PSD-95 protein in prefrontal cortex from people with schizophrenia.NPJ schizophrenia · 2015Article
- Increased G protein-coupled receptor kinase (GRK) expression in the anterior cingulate cortex in schizophrenia.Schizophrenia research · 2014Article
- Altered serine/threonine kinase activity in schizophrenia.Brain research · 2014Article
- Glutamatergic postsynaptic density protein dysfunctions in synaptic plasticity and dendritic spines morphology: relevance to schizophrenia and other behavioral disorders pathophysiology, and implications for novel therapeutic approaches.Molecular neurobiology · 2014Review
- Postmortem brain: an underutilized substrate for studying severe mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Review
- Effects of chronic electroacupuncture on depression- and anxiety-like behaviors in rats with chronic neuropathic pain.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Globularity and language-readiness: generating new predictions by expanding the set of genes of interest.Frontiers in psychology · 2014Article
- 1-42 β-amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death.Translational psychiatry · 2013Article
- PDE4 inhibition enhances hippocampal synaptic plasticity in vivo and rescues MK801-induced impairment of long-term potentiation and object recognition memory in an animal model of psychosis.Translational psychiatry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NMDA receptor hypofunction in schizophrenia has been inferred by a large number of clinical and preclinical observations; however, whether and how NMDA receptors are exactly involved in the pathogenesis of schizophrenia are still unknown and subject to interpretation. Here we show, in two independent samples of brains from patients with schizophrenia, a significant decrease in the phosphorylation level at serine 897 (S897) of the NMDA receptor type 1 (NR1) subunit. Our finding, together with a previous report that antipsychotics increase phosphorylation of NR1 at S897 in vivo, strongly suggests that insufficient phosphorylation at S897 may contribute to the neuronal pathology underlying schizophrenia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.