ArticleThe Plant cell2004
The F-box protein ZEITLUPE confers dosage-dependent control on the circadian clock, photomorphogenesis, and flowering time.
Article in The Plant cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
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Who cites it
112 citing papers in PubMed, 242 citations in OpenAlex.
- Light at the heart of time: How photoreceptors entrain the circadian clock.Plant communications · 2026Review
- Flowering time regulation: a critical review focusing on FKF1 protein.Plant molecular biology · 2026Review
- TOC1 phosphorylation disproportionally enhances chromatin binding at rhythmic gene promoters.Science advances · 2025Article
- Agrobacterium-mediated transformation of B. juncea reveals that BjuLKP2 functions in plant yellowing.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- 40S Ribosomal protein S6 kinase integrates daylength perception and growth regulation in Arabidopsis thaliana.Plant physiology · 2024Article
- Circadian and photoperiodic regulation of the vegetative to reproductive transition in plants.Communications biology · 2024Review
- Regulation of endogenous hormone and miRNA in leaves of alfalfa (Medicago sativa L.) seedlings under drought stress by endogenous nitric oxide.BMC genomics · 2024Article
- Genome-wide identification and characterization of flowering genes in Citrus sinensis (L.) Osbeck: a comparison among C. Medica L., C. Reticulata Blanco, C. Grandis (L.) Osbeck and C. Clementina.BMC genomic data · 2024Article
- AtSNP_TATAdb: Candidate Molecular Markers of Plant Advantages Related to Single Nucleotide Polymorphisms within Proximal Promoters ofInternational journal of molecular sciences · 2024Article
- Low temperature-mediated repression and far-red light-mediated induction determine morning FLOWERING LOCUS T expression levels.Journal of integrative plant biology · 2024Article
- Phytochrome-Interacting Proteins.Biomolecules · 2023Review
- Transcriptome profiling at the transition to the reproductive stage uncovers stage and tissue-specific genes in wheat.BMC plant biology · 2023Article
- Article
- PIFs- and COP1-HY5-mediated temperature signaling in higher plants.Stress biology · 2022Review
- The NaProceedings of the National Academy of Sciences of the United States of America · 2022Article
- The circadian clock mutant lhy cca1 elf3 paces starch mobilization to dawn despite severely disrupted circadian clock function.Plant physiology · 2022Article
- Genome-wide identification, evolutionary and functional analyses of KFB family members in potato.BMC plant biology · 2022Article
- Functional characterization of genes with daily expression patterns in common wheat.Plant molecular biology · 2022Article
- ZEITLUPE Promotes ABA-Induced Stomatal Closure in Arabidopsis andFrontiers in plant science · 2022Article
- The key clock component ZEITLUPE (ZTL) negatively regulates ABA signaling by degradation of CHLH in Arabidopsis.Frontiers in plant science · 2022Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As an F-box protein, ZEITLUPE (ZTL) is involved in targeting one or more substrates for ubiquitination and degradation via the proteasome. The initial characterization of ZTL suggested a function limited largely to the regulation of the circadian clock. Here, we show a considerably broader role for ZTL in the control of circadian period and photomorphogenesis. Using a ZTL-specific antibody, we quantitated and characterized a ZTL dosage series that ranges from a null mutation to a strong ZTL overexpressor. In the dark, ztl null mutations lengthen circadian period, and overexpression causes arrhythmicity, suggesting a more comprehensive role for this protein in the clock than previously suspected. In the light, circadian period becomes increasingly shorter at higher levels of ZTL, to the point of arrhythmicity. By contrast, hypocotyl length increases and flowering time is delayed in direct proportion to the level of ZTL. We propose a novel testable mechanism by which circadian period and amplitude may act together to gate phytochrome B-mediated suppression of hypocotyl. We also demonstrate that ZTL-dependent delay of flowering is mediated through decreases in CONSTANS and FLOWERING LOCUS T message levels, thus directly linking proteasome-dependent proteolysis to flowering.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.