ArticleVirology2004
Differential regulation of innate and adaptive immune responses in viral encephalitis.
Article in Virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
58 citing papers in PubMed, 94 citations in OpenAlex.
- Article
- Replication of Rocio virus in primary cultures of mouse neural cells.Einstein (Sao Paulo, Brazil) · 2023Article
- Multi-phenotype analysis for enhanced classification of 11 herpes simplex virus 1 strains.The Journal of general virology · 2022Article
- DJ-1-Nrf2 axis is activated upon murine β-coronavirus infection in the CNS.Brain disorders (Amsterdam, Netherlands) · 2021Article
- Article
- Insights into coronavirus immunity taught by the murine coronavirus.European journal of immunology · 2021Review
- Murine-β-coronavirus-induced neuropathogenesis sheds light on CNS pathobiology of SARS-CoV2.Journal of neurovirology · 2021Review
- Connecting Neuroinflammation and Neurodegeneration in Multiple Sclerosis: Are Oligodendrocyte Precursor Cells a Nexus of Disease?Frontiers in cellular neuroscience · 2021Review
- Neurobiology of coronaviruses: Potential relevance for COVID-19.Neurobiology of disease · 2020Review
- Microglia are required for protection against lethal coronavirus encephalitis in mice.The Journal of clinical investigation · 2018Article
- Role of the inflammasome-related cytokines Il-1 and Il-18 during infection with murine coronavirus.Journal of neurovirology · 2017Article
- Demyelinating strain of mouse hepatitis virus infection bridging innate and adaptive immune response in the induction of demyelination.Clinical immunology (Orlando, Fla.) · 2016Article
- The nsp3 macrodomain promotes virulence in mice with coronavirus-induced encephalitis.Journal of virology · 2015Article
- Ifit2 deficiency results in uncontrolled neurotropic coronavirus replication and enhanced encephalitis via impaired alpha/beta interferon induction in macrophages.Journal of virology · 2014Article
- Adaptive immune response to viral infections in the central nervous system.Handbook of clinical neurology · 2014Article
- Review
- Murine coronavirus neuropathogenesis: determinants of virulence.Journal of neurovirology · 2010Review
- Article
- Pathogenesis of murine coronavirus in the central nervous system.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010Review
- Accessory protein 5a is a major antagonist of the antiviral action of interferon against murine coronavirus.Journal of virology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Viral encephalitis is a global health concern. The ability of a virus to modulate the immune response can have a pivotal effect on the course of disease and the fate of the infected host. In this study, we sought to understand the immunological basis for the fatal encephalitis following infection with the murine coronavirus, mouse hepatitis virus (MHV)-JHM, in contrast with the more attenuated MHV-A59. Distinct glial cell cytokine and chemokine response patterns were observed within 3 days after infection, became progressively more polarized during the course of infection and with the infiltration of leukocytes. In the brain, MHV-JHM infection induced strong accumulation of IFNbeta mRNA relative to IFNgamma mRNA. This trend was reversed in MHV-A59 infection and was accompanied by increased CD8 T cell infiltration into brain compared to MHV-JHM infection. Increased apoptosis appeared to contribute to the diminished presence of CD8 T cells in MHV-JHM-infected brain with the consequence of a lower potential for IFNgamma production and antiviral activity. MHV-JHM infection also induced sustained mRNA accumulation of the innate immune response products interleukin (IL)-6 and IL-1. Furthermore, high levels of macrophage-inflammatory protein (MIP)-1alpha, MIP-1beta, and MIP-2 mRNA were observed at the onset of MHV-JHM infection and correlated with a marked elevation in the number of macrophages in the brain on day 7 compared to MHV-A59 infection. These observations indicate that differences in the severity of viral encephalitis may reflect the differential ability of viruses to stimulate innate immune responses within the CNS and subsequently the character of infiltrating leukocyte populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.