Evidence map›Paper›PMID 14972422›Full record

ArticleEuropean heart journal2004

Validation of coronary flow reserve measurements by thermodilution in clinical practice.

Emanuele Barbato, Wilbert Aarnoudse, Wim R Aengevaeren, Gerald Werner, Volker Klauss, Waldemar Bojara, Istvan Herzfeld, Keith G Oldroyd, Nico H J Pijls, Bernard De Bruyne and 1 more

Registry-linked trialAbstract readComparative StudyMulticenter StudyValidation Study
PubMed Publisher
In one paragraph

Article in European heart journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05392959 (Effect of the Antidiabetic Drug DAPAgliflozin on the Coronary Macrovascular and MICROvascular Function in Type 2 Diabetic Patients), which is not on this map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05392959 phase4terminatedstarted 2022, after this paper: background citation

Effect of the Antidiabetic Drug DAPAgliflozin on the Coronary Macrovascular and MICROvascular Function in Type 2 Diabetic Patients

Ran2022Enrolled4Registered outcomes3Posted comparisons0ConditionsDiabetes Mellitus, Type 2ArmsDapagliflozin 10 mg Tab, Placebo
PMID 20609968PMID 25538310PMID 25488697PMID 28254770PMID 7586302PMID 22340827PMID 21126613PMID 20566676PMID 19144937PMID 15466646PMID 12821539PMID 11705815other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Review
  6. Article
  7. Microbubble Contrast Agent Use During Invasive Coronary Microvascular Assessment.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
    Article
  8. ANOCA, INOCA, MINOCA: The New Frontier of Coronary Syndromes.Journal of cardiovascular development and disease · 2025
    Review
  9. Article
  10. Observational
  11. Absolute coronary blood flow across different endotypes of ANOCA.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
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  19. Review
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Emanuele BarbatoCardiovascular Center, OLV Ziekenhuis, Aalst, Belgium.
Wilbert Aarnoudse
Wim R Aengevaeren
Gerald Werner
Volker Klauss
Waldemar Bojara
Istvan Herzfeld
Keith G Oldroyd
Nico H J Pijls
Bernard De Bruyne
Week 25 study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronary flow reserve (CFR) and fractional flow reserve (FFR) provide complementary information on the coronary circulation. Using a pressure wire, it is possible to calculate CFR by thermodilution (CFR(thermo)), so that FFR and CFR can be measured with a single guide wire. The present multicentric study was performed to compare the feasibility of CFR(thermo)obtained with an improved algorithm and a standardized injection technique and its agreement with Doppler-derived CFR (CFR(Doppler)). METHODS AND

resultsIn 86 patients with coronary artery disease recruited during 1 week in eight centres FFR, CFR(thermo)and CFR(Doppler)were measured. FFR could be obtained in all patients (100%). An optimal CFR(Doppler)could be obtained in 69% of the patients. CFR(thermo)could be obtained in 97% of the patients. A significant correlation was found between CFR(Doppler)and CFR(thermo)(r=0.79, P<0.0001) but CFR(thermo)tended to be higher than CFR(Doppler).

conclusionsIn a setting close to 'real world' practice, this multicentric study confirms the feasibility and reliability of thermodilution-derived CFR. In addition, the safety and the swiftness of assessing FFR and CFR with one single guide wire makes the latter a unique clinical tool for the evaluation of the coronary circulation.

Indexed as

Coronary CirculationFeasibility StudiesHumansThermodilutionUltrasonography, Doppler

Identifiers

PMID14972422

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.