ArticleMolecular and cellular biochemistry2004
NF-kappaB prevents cells from undergoing Cr(VI)-induced apoptosis.
Article in Molecular and cellular biochemistry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- The effects of chromium(VI) on the thioredoxin system: implications for redox regulation.Free radical biology & medicine · 2012Review
- Hexavalent chromium Cr(VI) up-regulates COX-2 expression through an NFκB/c-Jun/AP-1-dependent pathway.Environmental health perspectives · 2012Article
- Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro.Toxicology and applied pharmacology · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factor NF-kappaB has been reported to prevent cells from undergoing apoptosis as well as promote cell apoptosis. To investigate the role of NF-kappaB in Cr(VI)-induced apoptosis, two cell lines were developed from human bronchial epithelial BEAS-2B cells: IKK cells, which were stably transfected with IkappaBalpha expression vector, that have normal NF-kappaB activity, and KM cells, which were stably transfected with mutated IkappaBalpha kinase expression vector, that exhibit very little NF-kappaB activity. With Cr(VI) stimulation, KM cells, but not IKK cells, exhibited substantial cell death. Cell morphological and TUNEL analyses indicated that the KM cells showed apoptotic features. These results suggest that NF-kappaB activation is required to prevent the cells from undergoing Cr(VI)-induced apoptosis.
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Registered trials
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