ArticleBritish journal of cancer2004
Identification and characterisation of constitutional chromosome abnormalities using arrays of bacterial artificial chromosomes.
Article in British journal of cancer, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Identification of metastasis-associated breast cancer genes using a high-resolution whole genome profiling approach.Journal of cancer research and clinical oncology · 2011Article
- Cytogenetic and cDNA microarray expression analysis of MCF10 human breast cancer progression cell lines.Cancer research · 2009Article
- Long tandem repeats as a form of genomic copy number variation: structure and length polymorphism of a chromosome 5p repeat in control and schizophrenia populations.Psychiatric genetics · 2009Article
- A comparative analysis of two tissue procurement approaches for the genomic profiling of clinical colorectal cancer samples.International journal of colorectal disease · 2008Article
- Consistent chromosome abnormalities identify novel polymicrogyria loci in 1p36.3, 2p16.1-p23.1, 4q21.21-q22.1, 6q26-q27, and 21q2.American journal of medical genetics. Part A · 2008Article
- A genome assembly-integrated dog 1 Mb BAC microarray: a cytogenetic resource for canine cancer studies and comparative genomic analysis.Cytogenetic and genome research · 2008Article
- Genome wide copy number abnormalities in pediatric medulloblastomas as assessed by array comparative genome hybridization.Brain pathology (Zurich, Switzerland) · 2007Article
- An approach to the validation of novel molecular markers of breast cancer via TMA-based FISH scanning.Journal of molecular histology · 2007Article
- From array to array: confirmation of genomic gains and losses discovered by array-based comparative genomic hybridization utilizing fluorescence in situ hybridization on tissue microarrays.Journal of molecular histology · 2007Article
- Gene-resolution analysis of DNA copy number variation using oligonucleotide expression microarrays.BMC genomics · 2007Article
- Array comparative genomic hybridisation (aCGH) analysis of premenopausal breast cancers from a nuclear fallout area and matched cases from Western New York.British journal of cancer · 2005Article
- A second field metachronous Merkel cell carcinoma of the lip and the palatine tonsil confirmed by microarray-based comparative genomic hybridisation.Virchows Archiv : an international journal of pathology · 2005Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Constitutional chromosome deletions and duplications frequently predispose to the development of a wide variety of cancers. We have developed a microarray of 6000 bacterial artificial chromosomes for array-based comparative genomic hybridisation, which provides an average resolution of 750 kb across the human genome. Using these arrays, subtle gains and losses of chromosome regions can be detected in constitutional cells, following a single overnight hybridisation. In this report, we demonstrate the efficiency of this procedure in identifying constitutional deletions and duplications associated with predisposition to retinoblastoma, Wilms tumour and Beckwith-Wiedemann syndrome.
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