ReviewBritish journal of cancer2004
ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia.
Review in British journal of cancer, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- The role of epigenetic modifications in hematological cancers.Frontiers in oncology · 2026Review
- Cardioprotective effect ofActa biochimica et biophysica Sinica · 2024Article
- Functional Roles of Bromodomain Proteins in Cancer.Cancers · 2021Review
- Pathogenic and Therapeutic Role of H3K4 Family of Methylases and Demethylases in Cancers.Indian journal of clinical biochemistry : IJCB · 2019Review
- MLL1 promotes cervical carcinoma cell tumorigenesis and metastasis through interaction with β-catenin.OncoTargets and therapy · 2016Article
- Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis.Oncogene · 2014Article
- Histone methylase MLL1 has critical roles in tumor growth and angiogenesis and its knockdown suppresses tumor growth in vivo.Oncogene · 2013Article
- Catalytic and functional roles of conserved amino acids in the SET domain of the S. cerevisiae lysine methyltransferase Set1.PloS one · 2013Article
- HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.Journal of molecular biology · 2011Article
- Article
- Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Histone methylases MLL1 and MLL3 coordinate with estrogen receptors in estrogen-mediated HOXB9 expression.Biochemistry · 2011Article
- The histone methyltransferase MLL1 permits the oscillation of circadian gene expression.Nature structural & molecular biology · 2010Article
- Genistein induces topoisomerase IIbeta- and proteasome-mediated DNA sequence rearrangements: Implications in infant leukemia.Biochemical and biophysical research communications · 2010Article
- Mixed lineage leukemia: a structure-function perspective of the MLL1 protein.The FEBS journal · 2010Review
- MLL fusions: pathways to leukemia.Cancer biology & therapy · 2009Review
- SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus.Molecular and cellular biology · 2008Article
- Differentially expressed genes are marked by histone 3 lysine 9 trimethylation in human cancer cells.Oncogene · 2008Article
- Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions.Genes & development · 2007Article
- Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth.Molecular and cellular biology · 2007Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Rearrangements of the ALL-1/MLL1 gene underlie the majority of infant acute leukaemias, as well as of therapy-related leukaemias developing in cancer patients treated with inhibitors of topoisomerase II, such as VP16 and doxorubicin. The rearrangements fuse ALL-1 to any of >50 partner genes or to itself. Here, we describe the unique features of ALL-1-associated leukaemias, and recent progress in understanding molecular mechanisms involved in the activity of the ALL-1 protein and of its Drosophila homologue TRITHORAX.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.