ArticleThe Journal of experimental medicine2004
Deficiency of the cyclin kinase inhibitor p21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoimmunity.
Article in The Journal of experimental medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8Nature communications · 2023Article
- TP53 and p21 (CDKN1A) polymorphisms and the risk of systemic lupus erythematosus.Advances in rheumatology (London, England) · 2023Article
- p21 produces a bioactive secretome that places stressed cells under immunosurveillance.Science (New York, N.Y.) · 2021Article
- DNA Damage Response in the Adaptive Arm of the Immune System: Implications for Autoimmunity.International journal of molecular sciences · 2021Review
- The ZNF76 rs10947540 polymorphism associated with systemic lupus erythematosus risk in Chinese populations.Scientific reports · 2021Article
- Differentially Expressed Gene Pathways in the Conjunctiva of Sjögren Syndrome Keratoconjunctivitis Sicca.Frontiers in immunology · 2021Article
- Contribution of B-1a cells to systemic lupus erythematosus in the NZM2410 mouse model.Annals of the New York Academy of Sciences · 2015Review
- Distinct p21 requirements for regulating normal and self-reactive T cells through IFN-γ production.Scientific reports · 2015Article
- Linking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosus.Disease models & mechanisms · 2014Review
- New roles for cyclin-dependent kinases in T cell biology: linking cell division and differentiation.Nature reviews. Immunology · 2014Review
- Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles.Nature genetics · 2012Article
- Bcl-xL enhances single-cell survival and expansion of human embryonic stem cells without affecting self-renewal.Stem cell research · 2012Article
- Negative selection assay based on stimulation of T cell receptor transgenic thymocytes with peptide-MHC tetramers.PloS one · 2012Article
- Elite control of HIV: p21 (waf-1/cip-1) at its best.Cell cycle (Georgetown, Tex.) · 2011Article
- Xenobiotic exposure and autoimmune hepatitis.Hepatitis research and treatment · 2010Article
- Accelerated pathological and clinical nephritis in systemic lupus erythematosus-prone New Zealand Mixed 2328 mice doubly deficient in TNF receptor 1 and TNF receptor 2 via a Th17-associated pathway.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle18) contributes to autoantibody production in 129 mice.Genes and immunity · 2009Article
- Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease.The Journal of experimental medicine · 2008Article
- Regulation of alloimmune Th1 responses by the cyclin-dependent kinase inhibitor p21 following transplantation.Surgery · 2008Article
- Cyclin-dependent kinases: molecular switches controlling anergy and potential therapeutic targets for tolerance.Seminars in immunology · 2007Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
A characteristic feature of systemic lupus erythematosus is the accumulation of activated/memory T and B cells. These G0/G1-arrested cells express high levels of cyclin-dependent kinase inhibitors such as p21, are resistant to proliferation and apoptosis, and produce large amounts of proinflammatory cytokines. Herein, we show that ablation of p21 in lupus-prone mice allows these cells to reenter the cell cycle and undergo apoptosis, leading to autoimmune disease reduction. Absence of p21 resulted in enhanced Fas/FasL-mediated activation-induced T cell death, increased activation of procaspases 8 and 3, and loss of mitochondrial transmembrane potential. Increased apoptosis was also associated with p53 up-regulation and a modest shift in the ratio of Bax/Bcl-2 toward the proapoptotic Bax. Proliferation and apoptosis of B cells were also increased in p21-/- lupus mice. Thus, modulation of the cell cycle pathway may be a novel approach to reduce apoptosis-resistant pathogenic lymphocytes and to ameliorate systemic autoimmunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.