Trial reportCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2004
Optimal duration of antibiotic therapy for uncomplicated urinary tract infection in older women: a double-blind randomized controlled trial.
Trial report in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Efficacy and safety of quinolones for the treatment of uncomplicated urinary tract infections in women: a network meta-analysis.International urogynecology journal · 2021Pooled it
- Antibiotic duration for treating uncomplicated, symptomatic lower urinary tract infections in elderly women.The Cochrane database of systematic reviews · 2008Pooled it
- Duration of antibacterial treatment for uncomplicated urinary tract infection in women.The Cochrane database of systematic reviews · 2005Pooled it
- Efficacy and safety of a novel once-daily extended-release ciprofloxacin tablet formulation for treatment of uncomplicated urinary tract infection in women.Antimicrobial agents and chemotherapy · 2005Trial
- Comparative risk of opioid overdose in patients who initiated antibiotics for urinary tract infection while on long-term opioid therapy.American journal of epidemiology · 2025Article
- Precision single cell analysis to characterize host dependent antimicrobial response heterogeneity in physiological medium.Lab on a chip · 2025Article
- Impact of an evidence-based order panel on antibiotic prescribing in ambulatory patients with cystitis.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Short-course intravenous beta-lactams for uncomplicated cystitis in hospitalized patients.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Plasmonic Fluorescence Sensors in Diagnosis of Infectious Diseases.Biosensors · 2024Review
- Evaluation of the Diagnosis and Antibiotic Prescription Pattern in Patients Hospitalized with Urinary Tract Infections: Single-Center Study from a University-Affiliated Hospital.Antibiotics (Basel, Switzerland) · 2023Article
- Three-day ceftriaxone versus longer durations of therapy for inpatient treatment of uncomplicated urinary tract infection.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2022Article
- The Five Ds of Outpatient Antibiotic Stewardship for Urinary Tract Infections.Clinical microbiology reviews · 2021Review
- In Vitro Killing of Canine Urinary Tract Infection Pathogens by Ampicillin, Cephalexin, Marbofloxacin, Pradofloxacin, and Trimethoprim/Sulfamethoxazole.Microorganisms · 2021Article
- In vitro killing of canine strains of Staphylococcus pseudintermedius and Escherichia coli by cefazolin, cefovecin, doxycycline and pradofloxacin over a range of bacterial densities.Veterinary dermatology · 2020Article
- Review
- Urinary tract infection in postmenopausal women.Korean journal of urology · 2011Article
- Diagnosis and management of urinary infections in older people.Clinical medicine (London, England) · 2011Review
- "Ten Commandments" for the Appropriate use of Antibiotics by the Practicing Physician in an Outpatient Setting.Frontiers in microbiology · 2011Article
- Review
- [Therapy of the acute uncomplicated urinary tract infection].Der Urologe. Ausg. A · 2006Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe optimal duration of antibiotic therapy in older patients with uncomplicated urinary tract infection (UTI) is still a matter of debate. The aim of this randomized controlled double-blind noninferiority trial was to compare the efficacy and safety of 3-day and 7-day courses of oral ciprofloxacin for uncomplicated symptomatic UTI in older women.
methodsA total of 183 women at least 65 years of age with acute uncomplicated UTI were recruited from ambulatory clinics and hospital acute care units. Patients with pyelonephritis, contraindications to fluoroquinolones, recent use of antibiotics, urinary tract abnormalities and diabetes mellitus were excluded. Women were randomly assigned to receive either ciprofloxacin 250 mg twice daily orally for 3 days followed by placebo for 4 days (the 3-day group, 93 patients) or ciprofloxacin 250 mg twice daily orally for 7 days (the 7-day group, 90 patients). Bacterial eradication, clinical improvement and occurrence of adverse events were determined 2 days after completion of treatment, and occurrence of reinfection or relapse were determined 6 weeks after completion of treatment. Bacterial eradication and relapse were determined by urine culture. Double-blind procedures were maintained throughout data collection.
resultsThe proportion of patients with bacterial eradication at 2 days after treatment was 98% (91/93) in the 3-day group and 93% (83/89) in the 7-day group (p = 0.16). The frequency of adverse events, including drowsiness, headache, nausea or vomiting, and loss of appetite, was significantly lower in the 3-day group.
interpretationThese results suggest that a 3-day course of antibiotic therapy is not inferior to a 7-day course for treatment of uncomplicated symptomatic UTI in older women, and that the shorter course is better tolerated.
Indexed as
Identifiers
14970093PMC332712W2137300329What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.