ArticleImmunogenetics2004
A single major chromosomal region controls natural killer cell-like activity in rainbow trout.
Article in Immunogenetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 73 citations in OpenAlex.
- Review
- Production and verification of a 2Scientific reports · 2016Article
- Characterization of the OmyY1 Region on the Rainbow Trout Y Chromosome.International journal of genomics · 2013Article
- A second generation integrated map of the rainbow trout (Oncorhynchus mykiss) genome: analysis of conserved synteny with model fish genomes.Marine biotechnology (New York, N.Y.) · 2012Article
- Analysis of BAC-end sequences in rainbow trout: content characterization and assessment of synteny between trout and other fish genomes.BMC genomics · 2011Article
- Detection of QTL with effects on osmoregulation capacities in the rainbow trout (Oncorhynchus mykiss).BMC genetics · 2011Article
- A first generation integrated map of the rainbow trout genome.BMC genomics · 2011Article
- Production of viable homozygous, doubled haploid channel catfish (Ictalurus punctatus).Marine biotechnology (New York, N.Y.) · 2010Article
- Estimates of linkage disequilibrium and effective population size in rainbow trout.BMC genetics · 2009Article
- A first generation BAC-based physical map of the rainbow trout genome.BMC genomics · 2009Article
- Article
- Mapping of five candidate sex-determining loci in rainbow trout (Oncorhynchus mykiss).BMC genetics · 2009Article
- NK gene complex dynamics and selection for NK cell receptors.Seminars in immunology · 2008Review
- A second generation genetic map for rainbow trout (Oncorhynchus mykiss).BMC genetics · 2008Article
- Article
- A type I and type II microsatellite linkage map of rainbow trout (Oncorhynchus mykiss) with presumptive coverage of all chromosome arms.BMC genomics · 2006Article
- Article
- Comparative genomics of natural killer cell receptor gene clusters.PLoS genetics · 2005Article
- Comparative mapping of expressed sequence tags containing microsatellites in rainbow trout (Oncorhynchus mykiss).BMC genomics · 2005Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the identification of a single major chromosomal region controlling natural killer (NK) cell-like activity in rainbow trout (Oncorhynchus mykiss). A genetic map based on 484 AFLP and 39 microsatellite genotypes from 106 doubled haploid fish was constructed. These fish were produced by androgenesis from a hybrid of two clonal lines divergent in NK-like activity. NK-like activities for 75 of the doubled haploids were quantified by an in vitro chromium release assay utilizing (51)Cr-labeled YAC-1 target cells. Composite interval mapping revealed a single major quantitative trait locus (QTL) associated with NK-like activity in this rainbow trout model. Genetic mapping revealed this QTL to also be unlinked to: fragmented MHC class I and MHC class II regions, the leukocyte receptor cluster, the natural killer cell enhancement factor ( NKEF) gene, the RAG-1 gene, and two QTL associated with resistance to infectious pancreatic necrosis virus in rainbow trout. Collectively, these results extend the utility of rainbow trout as an immunological model and are consistent with the idea that a single chromosomal region homologous to the natural killer cell complex (NKC) located on syntenic portions of mouse chromosome (Chr) 6, human Chr 12, and rat Chr 4 may exist in a lower vertebrate model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.