ArticleOncogene2004
Deacetylase recruitment by the C/H3 domain of the acetyltransferase p300.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Fli1 represses transcription of the human α2(I) collagen gene by recruitment of the HDAC1/p300 complex.PloS one · 2013Trial
- The SNL Histone Deacetylase-Binding Factor GmHE13 Is a Novel Regulator of Soybean Hypocotyl Elongation.Plant biotechnology journal · 2025Article
- Article
- Epstein-Barr Virus Nuclear Antigen Leader Protein Coactivates EP300.Journal of virology · 2018Article
- Protein lysine acetylation by p300/CBP.Chemical reviews · 2015Review
- Histone deacetylase 1 and p300 can directly associate with chromatin and compete for binding in a mutually exclusive manner.PloS one · 2014Article
- Quantitative dynamics of the link between cellular metabolism and histone acetylation.The Journal of biological chemistry · 2013Article
- Epigenetic mechanisms in learned fear: implications for PTSD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Review
- SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity.BMC molecular biology · 2012Article
- Physical and functional HAT/HDAC interplay regulates protein acetylation balance.Journal of biomedicine & biotechnology · 2011Review
- Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors.Journal of biomedicine & biotechnology · 2011Review
- Role of HDAC1 in senescence, aging, and cancer.Experimental gerontology · 2010Review
- AP-2gamma promotes proliferation in breast tumour cells by direct repression of the CDKN1A gene.The EMBO journal · 2009Article
- The transcriptional coactivator MAML1 regulates p300 autoacetylation and HAT activity.Nucleic acids research · 2009Article
- Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation.Molecular cell · 2007Article
- Histone deacetylase inhibitors synergize p300 autoacetylation that regulates its transactivation activity and complex formation.Cancer research · 2007Article
- Involvement of chromatin and histone deacetylation in SV40 T antigen transcription regulation.Nucleic acids research · 2007Article
- Effects of histone deacetylase inhibitors on HIF-1.Cell cycle (Georgetown, Tex.) · 2006Review
- pRb: master of differentiation. Coupling irreversible cell cycle withdrawal with induction of muscle-specific transcription.Oncogene · 2006Review
- Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha.The Journal of biological chemistry · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
The balance between acetylation and deacetylation of histone and nonhistone proteins controls gene expression in a variety of cellular processes, with transcription being activated by acetyltransferases and silenced by deacetylases. We report here the formation and enzymatic characterization of a complex between the acetyltransferase p300 and histone deacetylases. The C/H3 region of p300 was found to co-purify deacetylase activity from nuclear cell extracts. A prototype of class I histone deacetylases, HDAC1, interacts with p300 C/H3 domain in vitro and in vivo. The p300-binding protein E1A competes with HDAC1 for C/H3 binding; and, like E1A, HDAC1 overexpression interferes with either activation of Gal4p300 fusion protein or p300-dependent co-activation of two C/H3-binding proteins, MyoD and p53. The exposure to deacetylase inhibitors could reverse the dominant-negative effect of a C/H3 fragment insulated from the rest of the molecule, on MyoD- and p53-dependent transcription, whereas inhibition by E1A was resistant to trichostatin A. These data support the hypothesis that association between acetyltransferases and deacetylases can control the expression of genes implicated in cellular growth and differentiation, and suggest that the dominant-negative effect of the p300 C/H3 fragment relies on deacetylase recruitment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.