ArticleThe Biochemical journal2004
Tissue-specific loss of fucosylated glycolipids in mice with targeted deletion of alpha(1,2)fucosyltransferase genes.
Article in The Biochemical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- SC134-deruxtecan, a fucosyl-GM1 targeting ADC for small cell lung cancer therapy.Journal of translational medicine · 2025Article
- Glycosyltransferases: glycoengineers in human milk oligosaccharide synthesis and manufacturing.Frontiers in molecular biosciences · 2025Review
- Cancer-Associated Glycosphingolipids as Tumor Markers and Targets for Cancer Immunotherapy.International journal of molecular sciences · 2021Review
- Profiling natural serum antibodies of non-human primates with a carbohydrate antigen microarray.Xenotransplantation · 2020Article
- Article
- Std fimbriae-fucose interaction increases Salmonella-induced intestinal inflammation and prolongs colonization.PLoS pathogens · 2019Article
- Fucosyltransferase 1 and 2 play pivotal roles in breast cancer cells.Cell death discovery · 2019Article
- Enhanced fucosylation of GA1 in the digestive tracts of X-ray-irradiated mice.Glycoconjugate journal · 2017Article
- An overview of the lagomorph immune system and its genetic diversity.Immunogenetics · 2016Review
- Neofunctionalization of the Sec1 α1,2fucosyltransferase paralogue in leporids contributes to glycan polymorphism and resistance to rabbit hemorrhagic disease virus.PLoS pathogens · 2015Article
- Fucosyltransferase 1 mediates angiogenesis in rheumatoid arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2014Article
- Use of gnotobiotic mice to identify and characterize key microbes responsible for the development of the intestinal immune system.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2014Review
- Changes in bacterial glycolipids as an index of intestinal lactobacilli and epithelial glycolipids in the digestive tracts of mice after administration of penicillin and streptomycin.Glycoconjugate journal · 2013Article
- Mucin-type O-glycans and their roles in intestinal homeostasis.Glycobiology · 2013Review
- Association of fucosyltransferase 2 gene variants with ulcerative colitis in Han and Uyghur patients in China.World journal of gastroenterology · 2012Article
- Unique biological activity of botulinum D/C mosaic neurotoxin in murine species.Infection and immunity · 2012Article
- Assessment of the molecular expression and structure of gangliosides in brain metastasis of lung adenocarcinoma by an advanced approach based on fully automated chip-nanoelectrospray mass spectrometry.Journal of the American Society for Mass Spectrometry · 2011Article
- Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.Nature genetics · 2011Article
- Excretion into feces of asialo GM1 in the murine digestive tract and Lactobacillus johnsonii exhibiting binding ability toward asialo GM1. A possible role of epithelial glycolipids in the discharge of intestinal bacteria.Glycoconjugate journal · 2011Article
- Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.Human molecular genetics · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Glycolipids in epithelial tissues of the gastrointestinal tract act as receptors for enteric bacteria and are implicated in the activation of the intestinal immune system. To clarify the genes involved in the fucosylation of the major glycolipids, substrate glycolipids and fucosylated products were measured in tissues of wild-type and mutant mice lacking alpha(1,2)fucosyltransferase genes FUT1 or FUT2. Quantitative determination was performed by TLC-immunostaining for GA1 (Gg4Cer), FGA1 (fucosyl GA1), GM1 (II3NeuAc-Gg4Cer), FGM1 (fucosyl GM1), and Forssman glycolipids. Both FGM1 and FGA1 completely disappeared from the antrum, cecum, and colon of FUT2-null mice, but not those of FUT1-null and wild-type mice. Precursor glycolipids, GM1 and GA1, accumulated in tissues of FUT2-null mice, indicating that the FUT2-encoded enzyme preferentially participates in the fucosylation of GA1 and GM1 in these tissues. Female reproductive organs were similarly found to utilize FUT2 for the fucosylation of glycolipids FGA1 (uterus and cervix), and FGM1 (ovary), due to their absence in FUT2-null mice. In FUT1-null mice FGA1 was lost from the pancreas, but was present in wild-type and FUT2-null mice, indicating that FUT1 is essential for fucosylation of GA1 in the pancreas. Ulex europaeus agglutinin-I lectin histochemistry for alpha(1,2)fucose residues confirmed the absence of alpha(1,2)fucose residues from the apical surface of pancreatic acinar glands of FUT1-null mice. Ileum, epididymis, and testis retained specific fucosylated glycolipids, irrespective of targeted deletion of either gene, indicating either compensation for or redundancy of the alpha(1,2)fucosyltransferase genes in these tissues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.