ArticleWorld journal of gastroenterology2004
Helicobacter species sequences in liver samples from patients with and without hepatocellular carcinoma.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Relationship ofCanadian journal of gastroenterology & hepatology · 2023Pooled it
- Association between the presence of H pylori in the liver and hepatocellular carcinoma: a meta-analysis.World journal of gastroenterology · 2008Pooled it
- Article
- Validation of Multiplex PCR and Serology DetectingMicroorganisms · 2023Article
- Eradication of Helicobacter pylori alleviates lipid metabolism deterioration: a large-cohort propensity score-matched analysis.Lipids in health and disease · 2022Article
- Review
- Coinfection ofJournal of clinical medicine research · 2021Article
- Pre-Treatment with Grape Seed Extract Reduces Inflammatory Response and Oxidative Stress Induced byAntioxidants (Basel, Switzerland) · 2021Article
- Infection withPathogens (Basel, Switzerland) · 2020Article
- Zhidai Decoction Inhibits Cervical Cancer through Regulation of Vaginal Microbiota.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Article
- Cancer risk in chronic rhinosinusitis: a propensity score matched case-control cohort study.American journal of translational research · 2019Article
- Helicobacter infection in the hepatobiliary system and hepatic lesions: a possible association in dogs.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019Article
- Review
- Review
- Helicobacter pylori Infection as a Risk Factor for Hepatocellular Carcinoma: A Case-Control Study in Ethiopia.International journal of hepatology · 2018Article
- Diagnosis of Genus Helicobacter through a hemi-nested PCR assay of 16S rRNA.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2016Article
- Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases.World journal of hepatology · 2015Review
- From the stomach to other organs: Helicobacter pylori and the liver.World journal of hepatology · 2015Review
- Association between Helicobacter spp. infections and hepatobiliary malignancies: a review.World journal of gastroenterology · 2015Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimOnly a minority of patients carrying a defined viral aetiologic agent develop cirrhosis and ultimately hepatocellular carcinoma (HCC), the mechanism underlying the worsening is still undefined. Experimental infection by Helicobacter hepaticus in mice causes chronic hepatitis and HCC and recently, more Helicobacter species (Helicobacter spp.) have been detected in the liver of patients suffering from cholestatic diseases and HCC arising from non-cirrhotic liver. We investigated whether Helicobacter spp. sequences could be detected in the liver of patients with cirrhosis and HCC compared to subjects with metastasis to liver from colon cancer.
methodsTwenty-three liver samples from patients operated upon for HCC superimposed on hepatitis C virus (HCV)-related cirrhosis and 6 from patients with resected metastases from colorectal cancer, were tested by polymerase chain reaction for presence of genomic 16S rRNA of Helicobacter genus using specific primers. DNA sequencing and cag A gene analysis were also performed.
resultsGenomic sequences of Helicobacter spp. were found in 17 of 20 (85%) liver samples from patients with HCC and in 2 of 6 samples from patients with liver metastasis. In three samples of the first group the result was uncertain. H pylori was revealed in 16 out of 17 positive samples and Helicobacter pullorum in the other.
conclusionHelicobacter spp., carcinogenic in mice, were found at a higher frequency in the liver of patients with HCV-related cirrhosis and HCC than those in patients without primary liver disease.
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