ArticleWorld journal of gastroenterology2004
Expression of pituitary tumor transforming gene in human gastric carcinoma.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Identification of critical genes in gastric cancer to predict prognosis using bioinformatics analysis methods.Annals of translational medicine · 2020Article
- Prognostic implications of securin expression and sub-cellular localization in human breast cancer.Cellular oncology (Dordrecht, Netherlands) · 2016Article
- Pituitary tumor-transforming gene-1 serves as an independent prognostic biomarker for gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2016Article
- Overexpression of the pituitary tumor transforming gene upregulates metastasis in malignant neoplasms of the human salivary glands.Experimental and therapeutic medicine · 2015Article
- Mir-655 up-regulation suppresses cell invasion by targeting pituitary tumor-transforming gene-1 in esophageal squamous cell carcinoma.Journal of translational medicine · 2013Article
- Pituitary tumor-transforming gene 1 is expressed in primary ductal breast carcinoma, lymph node infiltration, and distant metastases.Disease markers · 2013Article
- The pituitary tumor transforming gene in thyroid cancer.Journal of endocrinological investigation · 2012Review
- Genetic aspects of gastric cancer instability.TheScientificWorldJournal · 2012Review
- Securin promotes the identification of favourable outcome in invasive breast cancer.British journal of cancer · 2009Article
- Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma.Cancer research · 2008Article
- The pituitary tumor transforming gene 1 (PTTG-1): an immunological target for multiple myeloma.Journal of translational medicine · 2008Article
- PTTG is a secretory protein in human pituitary adenomas and in mouse pituitary tumor cell lines.Endocrine pathology · 2007Article
- Predicting survival within the lung cancer histopathological hierarchy using a multi-scale genomic model of development.PLoS medicine · 2006Article
- The emerging role of pituitary tumor transforming gene in tumorigenesis.Clinical medicine & research · 2006Review
- The influence of the pituitary tumor transforming gene-1 (PTTG-1) on survival of patients with small cell lung cancer and non-small cell lung cancer.Journal of carcinogenesis · 2006Article
- PTTG overexpression is correlated with angiogenesis in human pituitary adenomas.Endocrine pathology · 2006Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimPituitary tumor transforming gene (PTTG1) is overexpressed in a variety of tumors, including carcinomas of the lung, breast, colon, as well as in leukemia, lymphoma and pituitary adenomas. However, there is little information on its expression in gastric carcinoma. We sought to investigate the expression of PTTG1 in gastric carcinoma and to explore the relationship between its expression and clinicopathological factors.
methodsWe studied 75 primary human gastric adenocarcinomas, including 17 mucosal carcinomas, 21 submucosal infiltrative carcinomas, 12 carcinomas invading proprial muscle layers, 6 carcinomas reaching the subserosa, and 19 carcinomas penetrating the serosal surface. Immunohistochemical analysis was performed using paraffin-embedded sections of gastric adenocarcinomas.
resultsPTTG1 was expressed heterogeneously in carcinomas. Positive PTTG1 staining was observed in 65.3% of the carcinomas (49 of 75). Its expression did not correlate significantly with either the histological type or the depth of infiltration of the gastric carcinomas. However, a statistical analysis showed significant differences between the primary adenocarcinomas and the associated metastatic lymph nodes.
conclusionThe results of this study demonstrate that PTTG1 expression is enhanced in metastatic lymph nodes in comparison to that in primary carcinomas. We suggest that PTTG1 may contribute to lymph node metastases in gastric carcinoma.
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