ArticlePLoS biology2004
Design and diversity in bacterial chemotaxis: a comparative study in Escherichia coli and Bacillus subtilis.
Article in PLoS biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Sigma B regulated motility and chemotaxis inMicrobiology (Reading, England) · 2026Article
- Bamboo Biochar and Sodium Silicate Alleviate Oxybenzone-Induced Phytotoxicity via Distinct Mechanisms for Sustainable Plant Protection.Plants (Basel, Switzerland) · 2025Article
- Article
- Flagellar point mutation causes social aggregation in laboratory-adaptedJournal of bacteriology · 2024Article
- Individual bacterial cells can use spatial sensing of chemical gradients to direct chemotaxis on surfaces.Nature microbiology · 2024Article
- Protein-protein complexes can undermine ultrasensitivity-dependent biological adaptation.Journal of the Royal Society, Interface · 2023Article
- Genome analysis of a halophilicFrontiers in microbiology · 2023Article
- Ultrasensitivity and bistability in covalent-modification cycles with positive autoregulation.Proceedings. Mathematical, physical, and engineering sciences · 2021Article
- From Modules to Networks: a Systems-Level Analysis of the Bacitracin Stress Response in Bacillus subtilis.mSystems · 2020Article
- The Mechanism of Bidirectional pH Taxis in Bacillus subtilis.Journal of bacteriology · 2020Article
- Regulation of the chemotaxis histidine kinase CheA: A structural perspective.Biochimica et biophysica acta. Biomembranes · 2020Review
- A di-iron protein recruited as an Fe[II] and oxygen sensor for bacterial chemotaxis functions by stabilizing an iron-peroxy species.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Dynamic domain arrangement of CheA-CheY complex regulates bacterial thermotaxis, as revealed by NMR.Scientific reports · 2017Article
- Ultrasensitivity and fluctuations in the Barkai-Leibler model of chemotaxis receptors in Escherichia coli.PloS one · 2017Article
- Study of intra-inter species protein-protein interactions for potential drug targets identification and subsequent drug design for Escherichia coli O104:H4 C277-11.In silico pharmacology · 2016Article
- Article
- Derivation of the bacterial run-and-tumble kinetic equation from a model with biochemical pathway.Journal of mathematical biology · 2016Article
- Adaptive Responses Limited by Intrinsic Noise.PloS one · 2015Article
- Macroscopic equations for bacterial chemotaxis: integration of detailed biochemistry of cell signaling.Journal of mathematical biology · 2015Article
- A network characteristic that correlates environmental and genetic robustness.PLoS computational biology · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Comparable processes in different species often involve homologous genes. One question is whether the network structure, in particular the feedback control structure, is also conserved. The bacterial chemotaxis pathways in E. coli and B. subtilis both regulate the same task, namely, excitation and adaptation to environmental signals. Both pathways employ many orthologous genes. Yet how these orthologs contribute to network function in each organism is different. To investigate this problem, we propose what is to our knowledge the first computational model for B. subtilis chemotaxis and compare it to previously published models for chemotaxis in E. coli. The models reveal that the core control strategy for signal processing is the same in both organisms, though in B. subtilis there are two additional feedback loops that provide an additional layer of regulation and robustness. Furthermore, the network structures are different despite the similarity of the proteins in each organism. These results demonstrate the limitations of pathway inferences based solely on homology and suggest that the control strategy is an evolutionarily conserved property.
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