ArticleMolecular psychiatry2004
Linkage of bipolar affective disorder on chromosome 8q24: follow-up and parametric analysis.
Article in Molecular psychiatry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of genome-wide association studies of antipsychotic response.Pharmacogenomics · 2019Pooled it
- CaFrontiers in cellular neuroscience · 2023Article
- Genomics in Treatment Development.Advances in neurobiology · 2023Article
- CaFrontiers in pharmacology · 2022Review
- A genome-wide screen for acrophobia susceptibility loci in a Finnish isolate.Scientific reports · 2016Article
- Dissecting bipolar disorder complexity through epigenomic approach.Molecular psychiatry · 2016Review
- A genome-wide association study of clinical symptoms of dissociation in a trauma-exposed sample.Depression and anxiety · 2014Article
- Heritability and linkage analysis of personality in bipolar disorder.Journal of affective disorders · 2013Article
- A review of potassium channels in bipolar disorder.Frontiers in genetics · 2013Article
- Converging Evidence for Epistasis between ANK3 and Potassium Channel Gene KCNQ2 in Bipolar Disorder.Frontiers in genetics · 2013Article
- Dysfunction of the Heteromeric KV7.3/KV7.5 Potassium Channel is Associated with Autism Spectrum Disorders.Frontiers in genetics · 2013Article
- Family-based association analysis to finemap bipolar linkage peak on chromosome 8q24 using 2,500 genotyped SNPs and 15,000 imputed SNPs.Bipolar disorders · 2010Article
- Genome-wide parametric linkage analyses of 644 bipolar pedigrees suggest susceptibility loci at chromosomes 16 and 20.Psychiatric genetics · 2008Article
- The genetics of bipolar disorder: genome 'hot regions,' genes, new potential candidates and future directions.Molecular psychiatry · 2008Review
- Family-based SNP association study on 8q24 in bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2008Article
- A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder.Molecular psychiatry · 2008Article
- PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder.The pharmacogenomics journal · 2007Article
- Quantitative trait locus analysis of nonverbal communication in autism spectrum disorder.Molecular psychiatry · 2006Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our group first reported a linkage finding for bipolar (BP) disorder on chromosome 8q24 in a study of 50 multiplex pedigrees, with an HLOD score reaching 2.39. Recently, Cichon et al reported an LOD score of 3.62 in the same region using two-point parametric analysis. Subsequently, we published the results of a genome scan for linkage to BP disorder using a sample extended to 65 pedigrees in which chromosome 8q24 provided the best finding, an NPL score of 3.13, approaching the accepted score for suggestive linkage. We have now fine mapped this region of chromosome 8 in our 65 pedigrees by the addition of 19 microsatellite markers reaching a marker density of 0.8 cM and an information content of 0.84. After the addition of the new data, the original NPL score slightly increased to 3.25. Two-point parametric analysis using the model employed by Cichon et al obtained an LOD score of 3.32 for marker D8S256 at theta=0.14 exceeding the proposed threshold for genomewide significance. After adjusting the parameters in accordance with the 'common disease-common variant' hypothesis, multipoint parametric analysis resulted in an HLOD of 2.49 (alpha=0.78) between D8S529 and D8S256, and defined a 1-LOD interval corresponding to a 2.3 Mb region. No allelic association with the disease was observed for our set of microsatellite markers. Biologically, plausible candidate genes in this region include thyroglobulin, KCNQ3 coding for a voltage-gated potassium channel and the gene for brain adenyl-cyclase (ADCY8).
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