ArticleMolecular psychiatry2004
Genome-wide scan for loci of Asperger syndrome.
Article in Molecular psychiatry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.Molecular autism · 2017Pooled it
- Can Asperger syndrome be distinguished from autism? An anatomic likelihood meta-analysis of MRI studies.Journal of psychiatry & neuroscience : JPN · 2011Pooled it
- A heterogeneity-based genome search meta-analysis for autism-spectrum disorders.Molecular psychiatry · 2006Pooled it
- Analysis of a Protein Network Related to Copy Number Variations in Autism Spectrum Disorder.Journal of molecular neuroscience : MN · 2019Article
- Replicated linear association between DUF1220 copy number and severity of social impairment in autism.Human genetics · 2015Article
- Family with sequence similarity 107: A family of stress responsive small proteins with diverse functions in cancer and the nervous system (Review).Biomedical reports · 2014Article
- Variants in several genomic regions associated with asperger disorder.Autism research : official journal of the International Society for Autism Research · 2010Article
- Mutation screening of NOS1AP gene in a large sample of psychiatric patients and controls.BMC medical genetics · 2010Article
- Identifying loci for the overlap between attention-deficit/hyperactivity disorder and autism spectrum disorder using a genome-wide QTL linkage approach.Journal of the American Academy of Child and Adolescent Psychiatry · 2010Article
- Communication, interventions, and scientific advances in autism: a commentary.Physiology & behavior · 2010Review
- Linkage and linkage disequilibrium scan for autism loci in an extended pedigree from Finland.Human molecular genetics · 2009Article
- Asperger syndrome.European child & adolescent psychiatry · 2009Review
- Asperger's syndrome in adulthood.Deutsches Arzteblatt international · 2009Review
- Advances in autism genetics: on the threshold of a new neurobiology.Nature reviews. Genetics · 2008Review
- Posterior probability of linkage analysis of autism dataset identifies linkage to chromosome 16.Psychiatric genetics · 2008Article
- Association of DISC1 with autism and Asperger syndrome.Molecular psychiatry · 2008Article
- Is ASMT a susceptibility gene for autism spectrum disorders? A replication study in European populations.Molecular psychiatry · 2007Article
- Mouse behavioral assays relevant to the symptoms of autism.Brain pathology (Zurich, Switzerland) · 2007Review
- The genetics of autistic disorders and its clinical relevance: a review of the literature.Molecular psychiatry · 2007Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asperger syndrome (AS), characterised by inadequate social interaction, lack of empathy and a dependence of routines and rituals, is classified as belonging to the autism spectrum disorders (DSM-IV and ICD-10). Although the prevalence of AS has been estimated to range from 0.3 up to 48.4 per 10 000, the phenotype still remains relatively unrecognised by clinicians. Several reports, including the original description by Hans Asperger (1944), have suggested that AS has a strong genetic component. Here, we have performed a genome-wide scan on Finnish families ascertained for AS with a strictly defined phenotype. In the initial scan, Z(max)>1.5 was observed on nine chromosomal regions, 1q21-22, 3p14-24, 3q25-27, 4p14, 4q32, 6p25, 6q16, 13q31-33 and 18p11. In the fine mapping stage, the highest two-point LOD scores were observed on chromosomes 1q21-22 (D1S484, Z(max dom)=3.58), 3p14-24 (D3S2432, Z(max dom)=2.50) and 13q31-33 (D13S793, Z(max dom)=1.59). The loci on 1q21-22 and 3p14-24 overlap with previously published autism susceptibility loci, and the loci on 1q21-22 and 13q31-33 overlap with the reported schizophrenia susceptibility loci. The present study is the first genome-wide screen in AS and therefore replication data sets are needed to evaluate further the significance of the AS-loci identified here.
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Registered trials
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