ArticleMolecular and cellular biology2004
DNA methylation may restrict but does not determine differential gene expression at the Sgy/Tead2 locus during mouse development.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Trichloroethylene-induced alterations in DNA methylation were enriched in polycomb protein binding sites in effector/memory CD4Environmental epigenetics · 2017Article
- Kremen1 regulates mechanosensory hair cell development in the mammalian cochlea and the zebrafish lateral line.Scientific reports · 2016Article
- The dual roles of geminin during trophoblast proliferation and differentiation.Developmental biology · 2014Article
- TEAD4 establishes the energy homeostasis essential for blastocoel formation.Development (Cambridge, England) · 2013Article
- Homeobox gene Rhox5 is regulated by epigenetic mechanisms in cancer and stem cells and promotes cancer growth.Molecular cancer · 2011Article
- Molecular signatures of the primitive prostate stem cell niche reveal novel mesenchymal-epithelial signaling pathways.PloS one · 2010Article
- The acrosomal protein Dickkopf-like 1 (DKKL1) is not essential for fertility.Fertility and sterility · 2010Article
- The acrosomal protein Dickkopf-like 1 (DKKL1) facilitates sperm penetration of the zona pellucida.Fertility and sterility · 2010Article
- Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I.The Journal of clinical investigation · 2009Article
- Molecular signatures of prostate stem cells reveal novel signaling pathways and provide insights into prostate cancer.PloS one · 2009Article
- Transglutaminase-1 gene mutations in autosomal recessive congenital ichthyosis: summary of mutations (including 23 novel) and modeling of TGase-1.Human mutation · 2009Review
- Identification of a small optimal subset of CpG sites as bio-markers from high-throughput DNA methylation profiles.BMC bioinformatics · 2008Article
- Epigenetic Basis for the Differentiation Potential of Mesenchymal and Embryonic Stem Cells.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2008Article
- Transcription factor TEAD2 is involved in neural tube closure.Genesis (New York, N.Y. : 2000) · 2007Article
- Stable CpG hypomethylation of adipogenic promoters in freshly isolated, cultured, and differentiated mesenchymal stem cells from adipose tissue.Molecular biology of the cell · 2006Article
- Epigenetic programming of mesenchymal stem cells from human adipose tissue.Stem cell reviews · 2006Review
- DkkL1 (Soggy), a Dickkopf family member, localizes to the acrosome during mammalian spermatogenesis.Molecular reproduction and development · 2005Article
- Programming the genome in embryonic and somatic stem cells.Journal of cellular and molecular medicineReview
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Soggy (Sgy) and Tead2, two closely linked genes with CpG islands, were coordinately expressed in mouse preimplantation embryos and embryonic stem (ES) cells but were differentially expressed in differentiated cells. Analysis of established cell lines revealed that Sgy gene expression could be fully repressed by methylation of the Sgy promoter and that DNA methylation acted synergistically with chromatin deacetylation. Differential gene expression correlated with differential DNA methylation, resulting in sharp transitions from methylated to unmethylated DNA at the open promoter in both normal cells and tissues, as well as in established cell lines. However, neither promoter was methylated in normal cells and tissues even when its transcripts were undetectable. Moreover, the Sgy promoter remained unmethylated as Sgy expression was repressed during ES cell differentiation. Therefore, DNA methylation was not the primary determinant of Sgy/Tead2 expression. Nevertheless, Sgy expression was consistently restricted to basal levels whenever downstream regulatory sequences were methylated, suggesting that DNA methylation restricts but does not regulate differential gene expression during mouse development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.