ArticlePlant physiology2004
Evolutionary dynamics of the DNA-binding domains in putative R2R3-MYB genes identified from rice subspecies indica and japonica genomes.
Article in Plant physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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85 citing papers in PubMed.
- Evolutionary and functional divergence of MYB regulatory networks in flavonoid biosynthesis across Poaceae, non-Poaceae monocots, and eudicot horticultural plants.Horticulture research · 2026Review
- GhMYB102 promotes Verticillium wilt resistance likely through modulation of lignin biosynthesis.Plant cell reports · 2026Article
- Genome-Wide Identification and Characterization of the MYB Transcription Factor Family inGenes · 2026Article
- Differences in lignification between hulled and hull-less Cucurbita pepo and functional identification of the key regulatory factor CpMYB52.Plant cell reports · 2026Article
- Genome-Wide Identification of the R2R3-MYB Gene Family Members in Masson Pine and the Regulation of Secondary Cell Wall Formation and Lignin Biosynthesis byPlants (Basel, Switzerland) · 2026Article
- Genome-wide identification of the oat (Avena sativa L.) R2R3-MYB gene family and expression analysis under different abiotic stresses.BMC plant biology · 2026Article
- Article
- Dark side of anthocyanin pigmentation.Plant biology (Stuttgart, Germany) · 2025Review
- Genome-Wide Analysis of the Common Fig (Ficus carica L.) R2R3-MYB Genes Reveals Their Structure, Evolution, and Roles in Fruit Color Variation.Biochemical genetics · 2025Article
- Systematic analysis of potato MYB family genes and their potential functions in anthocyanin biosynthesis.Scientific reports · 2025Article
- A chromosome-levelActa pharmaceutica Sinica. B · 2025Article
- Research progress on the synergistic regulation of MYB transcription factor-mediated developmental plasticity and stress responses in rice.Frontiers in plant science · 2025Review
- Genome-wide identification, expression analysis of the R2R3-MYB gene family and their potential roles under cold stress in Prunus sibirica.BMC genomics · 2024Article
- Genome-Wide Analysis ofPlants (Basel, Switzerland) · 2024Article
- Transcriptional regulation of flavonol biosynthesis in plants.Horticulture research · 2024Review
- Genome-Wide Identification and Analysis ofPlants (Basel, Switzerland) · 2023Article
- Genomic-wide identification and expression analysis of R2R3-MYB transcription factors related to flavonol biosynthesis in Morinda officinalis.BMC plant biology · 2023Article
- Review
- Genome-wide characterization and expression analysis of MYB transcription factors in Chrysanthemum nankingense.BMC plant biology · 2023Article
- NtMYB12 requires for competition between flavonol and (pro)anthocyanin biosynthesis in Narcissus tazetta tepals.Molecular horticulture · 2023Article
25 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
The molecular evolution of the R2R3-MYB gene family is of great interest because it is one of the most important transcription factor gene families in the plant kingdom. Comparative analyses of a gene family may reveal important adaptive changes at the protein level and thereby provide insights that relate structure to function. We have performed a range of comparative and bioinformatics analyses on R2R3-MYB genes identified from the rice (Oryza sativa subsp. japonica and indica) and Arabidopsis genome sequences. The study provides an initial framework to investigate how different evolutionary lineages in a gene family evolve new functions. Our results reveal a remarkable excess of non-synonymous substitutions, an indication of adaptive selection on protein structure that occurred during the evolution of both helix1 and helix2 of rice R2R3-MYB DNA-binding domains. These flexible alpha-helix regions associated with high frequencies of excess non-synonymous substitutions may play critical roles in the characteristic packing of R2R3-MYB DNA-binding domains and thereby modify the protein-DNA interaction process resulting in the recognition of novel DNA-binding sites. Furthermore, a co-evolutionary pattern is found between the second alpha-helix of the R2 domain and the second alpha-helix of the R3 domain by examining all the possible alpha-helix pairings in both the R2 and R3 domains. This points to the functional importance of pairing interactions between related secondary structures.
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