ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2004
Predicting complications from acute cough in pre-school children in primary care: a prospective cohort study.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Amoxicillin for acute lower respiratory tract infection in primary care: subgroup analysis of potential high-risk groups.The British journal of general practice : the journal of the Royal College of General Practitioners · 2014Trial
- Amoxicillin for acute lower respiratory tract infection in primary care: subgroup analysis by bacterial and viral aetiology.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2018Article
- Influence of the duration of penicillin prescriptions on outcomes for acute sore throat in adults: the DESCARTE prospective cohort study in UK general practice.The British journal of general practice : the journal of the Royal College of General Practitioners · 2017Article
- Antibiotic prescription strategies and adverse outcome for uncomplicated lower respiratory tract infections: prospective cough complication cohort (3C) study.BMJ (Clinical research ed.) · 2017Observational
- The Diagnosis of Urinary Tract Infection in Young Children (DUTY) Study Clinical Rule: Economic Evaluation.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2017Article
- Development and internal validation of a clinical rule to improve antibiotic use in children presenting to primary care with acute respiratory tract infection and cough: a prognostic cohort study.The Lancet. Respiratory medicine · 2016Article
- Community paediatric respiratory infection surveillance study protocol: a feasibility, prospective inception cohort study.BMJ open · 2016Article
- Predictors of suppurative complications for acute sore throat in primary care: prospective clinical cohort study.BMJ (Clinical research ed.) · 2013Article
- The TARGET cohort study protocol: a prospective primary care cohort study to derive and validate a clinical prediction rule to improve the targeting of antibiotics in children with respiratory tract illnesses.BMC health services research · 2013Observational
- Validation of a clinical rule to predict complications of acute cough in preschool children: a prospective study in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2007Article
- The case of 'protective fever and chest signs': towards a better understanding of general practice databases.The British journal of general practice : the journal of the Royal College of General Practitioners · 2007Article
- The use of infrared thermometry for the detection of fever.The British journal of general practice : the journal of the Royal College of General Practitioners · 2004Article
- The inter-observer agreement of examining pre-school children with acute cough: a nested study.BMC family practice · 2004Article
- Diagnosing coughs and colds.The British journal of general practice : the journal of the Royal College of General Practitioners · 2004Article
- Is dyspraxia a medical condition or a social disorder?The British journal of general practice : the journal of the Royal College of General Practitioners · 2004Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is uncertainty about which children with cough are most and least likely to experience complications.
aimTo derive a clinical prediction rule for complications in pre-school children presenting to primary care with acute cough. DESIGN OF STUDY: Prospective cohort study.
settingEight general practices in Leicestershire, United Kingdom.
methodPre-school children with cough for < or =28 days and without asthma were recruited. Sociodemographic, clinical history, and examination data were collected and univariable logistic regression used to explore the associations with complications. These were defined as any new symptom, sign or diagnosis identified by a primary care clinician at a parent initiated reconsultation, or hospital admission, before cough resolution. Those factors with stronger relationships (P< 0.2) were then modelled using multivariable logistic regression to identify the factors independently associated with complications.
resultsThe pre-test probability of complications was 10%. On univariable analysis, fever (odds ratio [OR] = 4.86; 95% confidence interval [CI] = 1.74 to 13.6), chest signs (OR = 2.72; CI = 1.06 to 6.96), and tachypnoea (OR = 3.80; CI = 1.22 to 11.8) were associated with complications. On multivariable analysis, only fever (OR = 5.56; CI = 1.75 to 17.6) and chest signs (OR = 2.88; CI = 1.02 to 8.05) were independently associated with complications. These ORs translate into post-test probabilities of complications of 6% for children with neither fever nor chest signs, 18% for children with chest signs, 28% for children with fever, and 40% for children with fever and chest signs.
conclusionsIf validated, this clinical prediction rule could be used to individualise the management of acute cough in pre-school children.
Indexed as
Identifiers
14965400PMC1314771W1772680619What OpenQuestion holds
Registered trials
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