ArticleCellular and molecular neurobiology2003
Effects of altered expression and localization of cyclophilin A on differentiation of p19 embryonic carcinoma cells.
Article in Cellular and molecular neurobiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- The emerging importance of immunophilins in fibrosis development.Molecular and cellular biochemistry · 2023Review
- Interaction of cyclophilin A with a novel binding protein, SR-25, and characterization of their expression pattern in Chinese hepatocellular carcinoma patients.Oncology letters · 2016Article
- The neuroprotective role of acupuncture and activation of the BDNF signaling pathway.International journal of molecular sciences · 2014Review
- RETRACTED: Cyclophilin A (CypA) interacts with NF-κB subunit, p65/RelA, and contributes to NF-κB activation signaling.PloS one · 2014Article
- Neural progenitors derived from human embryonic stem cells are targeted by allogeneic T and natural killer cells.Journal of cellular and molecular medicine · 2009Article
- Characterization of cyclophilin-encoding genes in Phytophthora.Molecular genetics and genomics : MGG · 2009Article
- Crystallization and preliminary X-ray crystallographic studies of human cyclophilin J.Acta crystallographica. Section F, Structural biology and crystallization communications · 2005Article
- Cyclophilin A is localized to the nucleus and controls meiosis in Saccharomyces cerevisiae.Eukaryotic cell · 2005Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
1. The retinoblastoma susceptibility gene product, p105Rb (RB), is an important regulator in the control of cell proliferation, differentiation, and apoptosis. Several cellular factors that complex with RB and exert their cellular regulatory functions have been identified, such as the RB:cyclophilin A (CypA) complex. 2. CypA is a cytoplasmic immunophilin and known for its involvement in T-cell differentiation and proliferation. Although CypA has a pivotal role in the immune response, its function in other signaling pathways is largely unknown. 3. In this study, we used a model of neuronal differentiation to demonstrate that the nuclear translocation of CypA, the appearance of hypophosphorylated RB and the enhancement of RB: CypA complex formation correlates with retinoic acid induced neuronal differentiation. 4. Inhibition of CypA expression results in repression of both the hypophosphorylated RB and the neuron-specific differentiation marker, class III beta tubulin. 5. The evidence of enriched CypA and colocalization of RB with CypA in the nucleus of primary adult sensory neurons substantiated the important event of RB-mediated neuronal differentiation of p19 EC cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.