ReviewCellular and molecular neurobiology2003
Mechanism of action of volatile anesthetics: role of protein kinase C.
Review in Cellular and molecular neurobiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 17 citations in OpenAlex.
- Structural Identification and Systematic Comparison of Phorbol Ester, Dioleoylglycerol, Alcohol and Sevoflurane Binding Sites in PKCδ C1A Domain.The protein journal · 2018Article
- Article
- Regional and temporal profiles of calpain and caspase-3 activities in postnatal rat brain following repeated propofol administration.Developmental neuroscience · 2010Article
- Anaesthetic mechanisms: update on the challenge of unravelling the mystery of anaesthesia.European journal of anaesthesiology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. It is not completely clear how volatile anesthetics cause anesthesia, but one possible consequence of their action is to alter presynaptic activity and the release of neurotransmitters due to alterations in intracellular signaling. 2. Protein kinase C (PKC) is a signal transducing enzyme that is an important regulator of multiple physiological processes like neurotransmitter release, ion channel activity, and neurotransmitter receptor desensitization. Thus, PKC is an attractive molecular target for the synaptic action of general anesthetics. 3. However, the effects of these agents on PKC activity are not yet fully understood and there are several contradictory data on the literature regarding the in vitro and in vivo preparations. 4. Here, we will review some evidence for volatile anesthetics effects on neuronal PKC activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.