ArticleNaunyn-Schmiedeberg's archives of pharmacology2004
Extracts from Rhois aromatica and Solidaginis virgaurea inhibit rat and human bladder contraction.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 35 citations in OpenAlex.
- Natural Products in the Treatment of Lower Urinary Tract Dysfunction and Infection.Handbook of experimental pharmacology · 2025Review
- Medicinal plants and natural products for treating overactive bladder.Chinese medicine · 2024Review
- Evaluating the Antioxidant and Antidiabetic Properties ofMolecules (Basel, Switzerland) · 2024Article
- An insight investigation to the antiurolithic activity of Trachyspermum ammi using the in vitro and in vivo experiments.Urolithiasis · 2023Article
- Review
- Article
- Antiurolithic activity of Origanum vulgare is mediated through multiple pathways.BMC complementary and alternative medicine · 2011Article
- Propiverine and metabolites: differences in binding to muscarinic receptors and in functional models of detrusor contraction.Naunyn-Schmiedeberg's archives of pharmacology · 2006Article
- Treatment of the overactive bladder syndrome with muscarinic receptor antagonists: a matter of metabolites?Naunyn-Schmiedeberg's archives of pharmacology · 2006Review
- Effects of ageing on muscarinic receptor subtypes and function in rat urinary bladder.Naunyn-Schmiedeberg's archives of pharmacology · 2005Article
- Editorial guidelines for manuscripts on the pharmacology of plant extracts.Naunyn-Schmiedeberg's archives of pharmacology · 2005Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since extracts from the plants Rhois aromatica and Solidaginis virgaurea are being used in the phytotherapy of bladder dysfunction including the overactive bladder syndrome, and since muscarinic receptors are the main pharmacological target in the treatment of bladder dysfunction, we have investigated whether these extracts can inhibit carbachol-induced, muscarinic receptor-mediated contraction of rat and human bladder. In vitro contraction experiments were performed with rat and human bladder strips. Radioligand binding and inositol phosphate accumulation studies were done with cells transfected with human M(2) or M(3) muscarinic receptors. Both extracts concentration-dependently (final concentrations 0.01-0.1%) inhibited carbachol-induced contraction of rat and human bladder with insurmountable antagonism. Radioligand binding experiments and inositol phosphate accumulation studies with cloned receptors demonstrated direct but non-competitive effects on muscarinic receptors. Reductions of KCl-induced bladder contraction demonstrated that inhibition by the higher extract concentrations also involved receptor-independent effects. We conclude that extracts from Rhois aromatica and Solidaginis virgaurea inhibit muscarinic receptor-mediated contraction of rat and human bladder. While this could contribute to the beneficial effects of these extracts in patients with bladder dysfunction, such therapeutic effects remain to be demonstrated in controlled clinical studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.