Evidence map›Paper›PMID 14963173›Full record

ArticleJournal of virology2004

Jaagsiekte sheep retrovirus envelope efficiently pseudotypes human immunodeficiency virus type 1-based lentiviral vectors.

Shan-Lu Liu, Christine L Halbert, A Dusty Miller

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Mechanisms for Env glycoprotein acquisition by retroviruses.AIDS research and human retroviruses · 2011
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Shan-Lu LiuDivision of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Christine L Halbert
A Dusty Miller
Fred Hutch Cancer Center · USUniversity of Washington · US

Funding

TRANSDUCTION OF BABOON HEMATOPOIETIC STEM CELLSP50HL054881 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BERNSTEIN, IRWIN · 1995 to 2004
$11.0M
PILOT STUDY--RETROVIRUS MEDIATED TRANSFER OF HUMAN GLUCOCEREBROSIDASE GENEP30DK047754 · NIDDK · UNIVERSITY OF WASHINGTON · PI MILLER, ARTHUR DUSTY · 1994 to 2008
$8.4M
MOLECULAR TRAINING PROGRAM IN CANCER RESEARCH - COMPETINT32CA009437 · NCI · UNIVERSITY OF WASHINGTON · PI LOEB, LAWRENCE A · 1985 to 2001
$1.1M
NCI NIH HHS T32 CA009437NCI NIH HHS T32-CA09437NHLBI NIH HHS HL54881NHLBI NIH HHS P50 HL054881NIDDK NIH HHS DK47754NIDDK NIH HHS P30 DK047754
6 · The paper itself

Abstract

Jaagsiekte sheep retrovirus (JSRV) infects lung epithelial cells in sheep, and oncoretroviral vectors bearing JSRV Env can mediate transduction of human cells, suggesting that such vectors might be useful for lung-directed gene therapy. Here we show that JSRV Env can also efficiently pseudotype a human immunodeficiency virus type 1-based lentiviral vector, a more suitable vector for transduction of slowly dividing lung epithelial cells. We created several chimeric Env proteins that, unlike the parental Env, do not transform rodent fibroblasts but are still capable of pseudotyping lentiviral and oncoretroviral vectors.

Indexed as

Amino Acid SequenceAnimalsCell Adhesion MoleculesCell DivisionCells, CulturedEpithelial CellsFibroblastsGene Products, envGenetic TherapyGenetic VectorsGPI-Linked ProteinsHIV-1HumansHyaluronoglucosaminidaseJaagsiekte sheep retrovirusLungCell Adhesion MoleculesGene Products, envGPI-Linked ProteinsHyal2 protein, humanHyaluronoglucosaminidaseReceptors, VirusRecombinant Fusion Proteins

Identifiers

PMID14963173
PMCPMC369219
OpenAlexW1995299425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.