ArticleJournal of virology2004
Bovine papillomavirus replicative helicase E1 is a target of the ubiquitin ligase APC.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Current status and future directions for the development of human papillomavirus vaccines.Frontiers in immunology · 2024Review
- How different viruses perturb host cellular machinery via short linear motifs.EXCLI journal · 2023Review
- Novel Antigenic Targets of HPV Therapeutic Vaccines.Vaccines · 2021Review
- Design and Immunological Validation ofFrontiers in immunology · 2021Article
- The full transcription map of mouse papillomavirus type 1 (MmuPV1) in mouse wart tissues.PLoS pathogens · 2017Article
- Activation of NF-κB by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1.Journal of virology · 2015Article
- The role of ubiquitin and ubiquitin-like modification systems in papillomavirus biology.Viruses · 2014Review
- The E1 proteins.Virology · 2013Review
- Control the host cell cycle: viral regulation of the anaphase-promoting complex.Journal of virology · 2013Review
- Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a.PLoS pathogens · 2012Article
- Global genomics and proteomics approaches to identify host factors as targets to induce resistance against Tomato bushy stunt virus.Advances in virus research · 2010Review
- Cdc34p ubiquitin-conjugating enzyme is a component of the tombusvirus replicase complex and ubiquitinates p33 replication protein.Journal of virology · 2008Article
- Replication and partitioning of papillomavirus genomes.Advances in virus research · 2008Review
- Nuclear import of bovine papillomavirus type 1 E1 protein is mediated by multiple alpha importins and is negatively regulated by phosphorylation near a nuclear localization signal.Journal of virology · 2007Article
- Nucleocytoplasmic shuttling of bovine papillomavirus E1 helicase downregulates viral DNA replication in S phase.Journal of virology · 2007Article
- A phosphorylation map of the bovine papillomavirus E1 helicase.Virology journal · 2006Article
- Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The papillomavirus E1 replicative helicase is essential for replication and maintenance of extrachromosomal viral genomes in infected cells. We previously found that the bovine papillomavirus E1 protein is a substrate of the ubiquitin-dependent proteolytic pathway. Here we show that E1 is targeted for degradation by the anaphase-promoting complex (APC). Inhibition of APC activity by the specific inhibitor Emi1 or point mutations in the D-box and KEN-box motifs of E1 stabilize the protein and increase viral DNA replication in both a cell-free system and in living cells. These findings involve APC as the ubiquitin ligase that controls E1 levels to maintain a constant low copy number of the viral genome during latent infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.