ArticleStructure (London, England : 1993)2004
Crystal structure of Mycoplasma arthritidis mitogen complexed with HLA-DR1 reveals a novel superantigen fold and a dimerized superantigen-MHC complex.
Article in Structure (London, England : 1993), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Novel insights into the immune response to bacterial T cell superantigens.Nature reviews. Immunology · 2024Review
- Review
- Cisplatin protects mice from challenge ofEmerging microbes & infections · 2019Article
- Pfit is a structurally novel Crohn's disease-associated superantigen.PLoS pathogens · 2013Article
- Crystal structure of the Mycoplasma arthritidis-derived mitogen in apo form reveals a 3D domain-swapped dimer.Journal of molecular biology · 2010Article
- Toxins from bacteria.EXS · 2010Review
- 3PFDB--a database of best representative PSSM profiles (BRPs) of protein families generated using a novel data mining approach.BioData mining · 2009Article
- The landscape of human proteins interacting with viruses and other pathogens.PLoS pathogens · 2008Article
- Zinc induces dimerization of the class II major histocompatibility complex molecule that leads to cooperative binding to a superantigen.The Journal of biological chemistry · 2007Article
- Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC.Nature structural & molecular biology · 2007Article
- Mutagenesis, biochemical, and biophysical characterization of Mycoplasma arthritidis-derived mitogen.Molecular immunology · 2007Article
- A single point mutation changes the crystallization behavior of Mycoplasma arthritidis-derived mitogen.Acta crystallographica. Section F, Structural biology and crystallization communications · 2006Article
- Expression, purification and crystallization of Streptococcus dysgalactiae-derived mitogen.Acta crystallographica. Section F, Structural biology and crystallization communications · 2006Article
- Crystal structures of T cell receptor (beta) chains related to rheumatoid arthritis.Protein science : a publication of the Protein Society · 2005Article
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6 authors.
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Abstract
Mycoplasma arthritidis-derived mitogen (MAM) is a superantigen that can activate large fractions of T cells bearing particular TCR Vbeta elements. Here we report the crystal structure of MAM complexed with a major histocompatibility complex (MHC) antigen, HLA-DR1, loaded with haemagglutinin peptide 306-318 (HA). The structure reveals that MAM has a novel fold composed of two alpha-helical domains. This fold is entirely different from that of the pyrogenic superantigens, consisting of a beta-grasped motif and a beta barrel. In the complex, the N-terminal domain of MAM binds orthogonally to the MHC alpha1 domain and the bound HA peptide, and to a lesser extent to the MHC beta1 domain. Two MAM molecules form an asymmetric dimer and cross-link two MHC antigens to form a plausible, dimerized MAM-MHC complex. These data provide the first crystallographic evidence that superantigens can dimerize MHC molecules. Based on our structure, a model of the TCR2MAM2MHC2 complex is proposed.
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