Evidence map›Paper›PMID 14960520›Full record

ArticleGut2004

Duodenal adenomatosis in familial adenomatous polyposis.

S Bülow, J Björk, I J Christensen, O Fausa, H Järvinen, F Moesgaard, H F A Vasen, DAF Study Group

2 registry-linked trialsOpen access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 150 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed, 4 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03346980 completednot on this mapstarted 2017, after this paper: background citation

Endoscopic Evaluation of Duodenal Polyposis in Patients With Familial Adenomatous Polyposis (FAP) - a Single Center Prospective Validation of the Spigelman Classification

Typeobservational_patient_registrySponsorCopenhagen University Hospital, HvidovreRan2017 to 2020Enrolled36ConditionsFamilial Adenomatous Polyposes, Duodenal Polyposis, Duodenal CancerArmsEsophagogastroduodenoscopy
NCT06435533 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Cold Atmospheric Plasma for the Endoscopic Treatment of Duodenal Polyps in Patients With Familial Adenomatous Polyposis

TypeinterventionalSponsorUniversitätsklinikum Hamburg-EppendorfRan2023 to 2025Enrolled10ConditionsAdenomatous Polyposis Coli, Familial Adenomatous Polyposis, Duodenal AdenomaArmslow energy argonplasma coagulation
3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 4 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

S BülowThe Danish Polyposis Register, Hvidovre University Hospital, Copenhagen, Denmark. sbulow@dadlnet.dk
J Björk
I J Christensen
O Fausa
H Järvinen
F Moesgaard
H F A Vasen
DAF Study Group
Hvidovre Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalence of duodenal carcinoma is much higher in familial adenomatous polyposis (FAP) than in the background population, and duodenal adenomatosis is found in most polyposis patients.

aimsTo describe the long term natural history of duodenal adenomatosis in FAP and evaluate if cancer prophylactic surveillance of the duodenum is indicated.

methodsA prospective five nation study was carried out in the Nordic countries and the Netherlands. PATIENTS: A total of 368 patients were examined by gastroduodenoscopy at two year intervals during the period 1990-2001.

resultsAt the first endoscopy, 238 (65%) patients had duodenal adenomas at a median age of 38 years. Median follow up was 7.6 years. The cumulative incidence of adenomatosis at age 70 years was 90% (95% confidence interval (CI) 79-100%), and of Spigelman stage IV 52% (95% CI 28-76%). The probability of an advanced Spigelman score increased during the study period (p<0.0001) due to an increasing number and size of adenomas. Two patients had asymptomatic duodenal carcinoma at their first endoscopy while four developed carcinoma during the study at a median age of 52 years (range 26-58). The cumulative incidence rate of cancer was 4.5% at age 57 years (95% CI 0.1-8.9%) and the risk was higher in patients with Spigelman stage IV at their first endoscopy than in those with stages 0-III (p<0.01).

conclusionsThe natural course of duodenal adenomatosis has now been described in detail. The high incidence and increasing severity of duodenal adenomatosis with age justifies prophylactic examination, and a programme is presented for upper gastrointestinal endoscopic surveillance.

Indexed as

Adenomatous Polyposis ColiAdolescentAdultAgedChildDisease ProgressionDuodenal DiseasesDuodenal NeoplasmsFemaleFollow-Up StudiesHumansIntestinal PolyposisMaleMiddle AgedNeoplasm StagingPopulation Surveillance

Identifiers

PMID14960520
PMCPMC1773976
OpenAlexW1893945215

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.