ArticleProceedings of the National Academy of Sciences of the United States of America1992
Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 140 citations in OpenAlex.
- Expression of eosinophil β chain-signaling cytokines receptors, outer-membrane integrins, and type 2 inflammation biomarkers in severe non-allergic eosinophilic asthma.BMC pulmonary medicine · 2019Trial
- Serum T2-High Inflammation Mediators in Eosinophilic COPD.Biomolecules · 2024Article
- Review
- Transcriptional Regulation of the Human IL5RA Gene through Alternative Promoter Usage during Eosinophil Development.International journal of molecular sciences · 2021Article
- Article
- Cytokine receptor splice variants in hematologic diseases.Cytokine · 2020Review
- RNA Splicing: A New Paradigm in Host-Pathogen Interactions.Journal of molecular biology · 2019Review
- Human group 2 innate lymphoid cells do not express the IL-5 receptor.The Journal of allergy and clinical immunology · 2017Article
- Splicing in immune cells-mechanistic insights and emerging topics.International immunology · 2017Review
- Splicing Regulation of Pro-Inflammatory Cytokines and Chemokines: At the Interface of the Neuroendocrine and Immune Systems.Biomolecules · 2015Review
- Interleukin 5 is protective during sepsis in an eosinophil-independent manner.American journal of respiratory and critical care medicine · 2012Article
- IL-5 receptor α levels in patients with marked eosinophilia or mastocytosis.The Journal of allergy and clinical immunology · 2011Article
- Cord blood molecular biomarkers of eosinophilopoiesis: kinetic analysis of GATA-1, MBP1 and IL-5R alpha mRNA expression.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2010Article
- Interleukin-5 receptor subunit oligomerization and rearrangement revealed by fluorescence resonance energy transfer imaging.The Journal of biological chemistry · 2008Article
- Slow-dissociation effect of common signaling subunit beta c on IL5 and GM-CSF receptor assembly.Cytokine · 2008Article
- Association analysis of interleukin 5 receptor alpha subunit (IL5RA) polymorphisms and asthma.Journal of human genetics · 2005Article
- Quantitative real time polymerase chain reaction for measurement of human interleukin-5 receptor alpha spliced isoforms mRNA.BMC biotechnology · 2003Article
- Regulation of the interleukin-5 receptor alpha-subunit on peripheral blood eosinophils from healthy subjects.Clinical and experimental immunology · 2003Article
- Multiple regions within the promoter of the murine Ifnar-2 gene confer basal and inducible expression.The Biochemical journal · 2002Article
- Proteasomal regulation of betac signaling reveals a novel mechanism for cytokine receptor heterotypic desensitization.The Journal of clinical investigation · 2001Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By use of a 3' extension PCR strategy, cDNA clones were isolated spanning the transmembrane region and a complete cytoplasmic domain of the human interleukin 5 receptor alpha subunit (hIL5R alpha). These cDNAs differ from previously isolated clones encoding a soluble hIL5R alpha form by a sequence switch at position 1243. When expressed in COS-1 cells, only low-affinity binding of 125I-labeled human interleukin 5 was observed. Coexpression of the hIL5R beta chain led to a 2-fold increase in binding affinity. In addition, this same cloning strategy allowed us to identify a putative second soluble isoform of hIL5R alpha. Genomic data revealed that the two soluble variants arise from either a "normal" splicing event or from the absence of splicing, whereas synthesis of the membrane-anchored form requires alternative splicing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.