ArticleProceedings of the National Academy of Sciences of the United States of America1992
Evolution of the mouse t haplotype: recent and worldwide introgression to Mus musculus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- Beyond the Prdm9 model: independent evolution of hybrid male sterility in house mice.Heredity · 2026Article
- A fascination with tailless mice: a scientific historical review of studies of the T/t complex.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- Meiotic drive in house mice: mechanisms, consequences, and insights for human biology.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2022Review
- Novel patterns of expression and recruitment of new genes on theProceedings. Biological sciences · 2022Article
- The baculum affects paternity success of first but not second males in house mouse sperm competition.BMC ecology and evolution · 2021Article
- Effects of a male meiotic driver on male and female transcriptomes in the house mouse.Proceedings. Biological sciences · 2019Article
- Rodent gene drives for conservation: opportunities and data needs.Proceedings. Biological sciences · 2019Article
- The potential of genomics for restoring ecosystems and biodiversity.Nature reviews. Genetics · 2019Review
- Complex History and Differentiation Patterns of theGenetics · 2018Article
- Meiotic drive changes sperm precedence patterns in house mice: potential for male alternative mating tactics?BMC evolutionary biology · 2016Article
- Prdm9 polymorphism unveils mouse evolutionary tracks.DNA research : an international journal for rapid publication of reports on genes and genomes · 2014Article
- A selfish genetic element influencing longevity correlates with reactive behavioural traits in female house mice (Mus domesticus).PloS one · 2013Article
- CRIS-a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending.PLoS genetics · 2013Article
- Genome patterns of selection and introgression of haplotypes in natural populations of the house mouse (Mus musculus).PLoS genetics · 2012Article
- Natural diversity in flowering responses of Arabidopsis thaliana caused by variation in a tandem gene array.Genetics · 2010Article
- Recombination within mouse t haplotypes has replaced significant segments of t-specific DNA.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- The dynamic of the t-haplotype in wild populations of the house mouse Mus musculus domesticus in Israel.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- The cld mutation: narrowing the critical chromosomal region and selecting candidate genes.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- Article
- Discordant phylogeographic patterns between the Y chromosome and mitochondrial DNA in the house mouse: selection on the Y chromosome?Genetics · 1997Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mouse t haplotypes are variants of chromosome 17, consisting of four inversions. Despite the homozygous lethality and pleiotropic effect on embryonic development, sperm production, and recombination, they have widely spread in natural populations of the house mouse (10-40% in frequency) because of the meiotic drive advantage. We sequenced 14 Tcp-1 (t-complex polypeptide 1) genes from four t haplotypes, nine wild mice, and a rat as a reference. From a comparison of intron sequences of 610 base pairs, we dated the origin of t haplotypes to 2.9 +/- 0.7 million years ago, which predates the splitting of Mus musculus subspecies (approximately 1 million years ago). However, the Tcp-1 intron sequences of t haplotypes from different M. musculus subspecies from various parts of the world show no divergence, indicating the recent introgression (no earlier than 0.8 million years ago) of a single ancestral type. Nucleotide changes in coding regions are also consistent with this conclusion. Hence, polymorphisms among t haplotypes including lethality factors have accumulated during this short time period independently in each M. musculus subspecies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.