ReviewInfection1992
The role of GM-CSF in infection.
Review in Infection, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Impact of Antifungal Compounds on Viability and Anti-Antimicrobial agents and chemotherapy · 2019Article
- Prophylactic Administration of Vector-Encoded Porcine Granulocyte-Colony Stimulating Factor Reduces Salmonella Shedding, Tonsil Colonization, and Microbiota Alterations of the Gastrointestinal Tract in Salmonella-Challenged Swine.Frontiers in veterinary science · 2016Article
- Apoptosis-associated uncoupling of bone formation and resorption in osteomyelitis.Frontiers in cellular and infection microbiology · 2013Review
- The effect of enzymatically polymerised polyphenols on CD4 binding and cytokine production in murine splenocytes.PloS one · 2012Article
- Osteoblast responses to bacterial pathogens: a previously unappreciated role for bone-forming cells in host defense and disease progression.Immunologic research · 2004Review
- Functional CD40 expression induced following bacterial infection of mouse and human osteoblasts.Infection and immunity · 2003Article
- Induction of colony-stimulating factor expression following Staphylococcus or Salmonella interaction with mouse or human osteoblasts.Infection and immunity · 2000Article
- Granulocyte-macrophage colony-stimulating factor in Staphylococcus aureus-induced arthritis.Infection and immunity · 1998Article
- Roles of tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, platelet-activating factor, and arachidonic acid metabolites in interleukin-1-induced resistance to infection in neutropenic mice.Infection and immunity · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GM-CSF is a hemopoietic growth factor with substantial effects on the proliferation of neutrophils, eosinophils and monocytes/macrophages. Its physiologic role in infection is still poorly understood. The gene for GM-CSF is constitutively transcribed in cells substantial for antiinfectious response. Various cells are activated and induced by TNF and IL-1 to synthesize GM-CSF. No systemic GM-CSF levels can be detected in patients with infection. It is likely that GM-CSF plays its physiological role in the immediate vicinity of the cells by which it is secreted. GM-CSF functionally activates neutrophils, monocytes/macrophages and eosinophils. It may augment T-cell proliferation and function. GM-CSF is effective in mice infected with Staphylococcus aureus or Salmonella typhimurium. Its effect in infectious disease in man should be explored.
Indexed as
Identifiers
1493940What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.