Evidence map›Paper›PMID 1493082›Full record

ArticleBritish journal of clinical pharmacology1992

The pharmacokinetics and pharmacodynamics of recombinant human erythropoietin in haemodialysis patients.

J Brockmöller, J Köchling, W Weber, M Looby, I Roots, H H Neumayer

Abstract read
PubMed Full text at PMC
In one paragraph

Article in British journal of clinical pharmacology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Article
  9. The greatly misunderstood erythropoietin resistance index and the case for a new responsiveness measure.Hemodialysis international. International Symposium on Home Hemodialysis · 2016
    Article
  10. Article
  11. Review
  12. Predictive modeling for improved anemia management in dialysis patients.Current opinion in nephrology and hypertension · 2011
    Review
  13. Article
  14. Review
  15. A 'bottom-up' approach for endo-PK/PD analysis.Biopharmaceutics & drug disposition · 2006
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

J BrockmöllerInstitute of Clinical Pharmacology, Klinikum Steglitz, Free University Berlin, Germany.
J Köchling
W Weber
M Looby
I Roots
H H Neumayer

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1. The pharmacokinetics of and therapeutic response to recombinant human erythropoietin (rcEPO) were studied in 12 patients under chronic haemodialysis on a thrice weekly intravenous rcEPO treatment scheme. The kinetics of rcEPO were also assessed after a subcutaneous injection during the initial period and during maintenance treatment. RcEPO was measured in plasma by radioimmunoassay. 2. After the first i.v. dose plasma erythropoietin concentrations were best described by a monoexponential disposition function with a mean (+/- s.d.) elimination half-life of 5.4 +/- 1.7 h. The volume of distribution was 70 +/- 5.2 ml kg-1 and the clearance was 10.1 +/- 3.5 ml h-1 kg-1 (n = 12). 3. After 3 months of continuous therapy, the plasma half-life of rcEPO decreased by 15% (P < 0.05, mean half-life during steady state: 4.6 +/- 2.8 h), while mean clearance and volume of distribution remained constant. 4. After the first s.c. injection the mean (+/- s.d.) absorption time was 22 +/- 11 h and systemic availability was 44 +/- 7%. 5. Changes in haemoglobin concentrations were described by a linear additive dose-response model, defined by an efficacy constant (Keff) and the mean erythrocyte lifetime (MRTHb). The sample mean (+/- s.d.) Keff was 0.043 +/- 0.017 g dl-1 Hb per 1000 units rcEPO and MRTHb was 10.02 +/- 1.75 weeks. The net effect of rcEPO treatment was described by the area under the unit-dose-response curve (AUEC) with a mean (+/- s.d.) value of 0.45 +/- 0.23 g dl-1 weeks. 6. RcEPO clearance showed a significant positive correlation (r2 = 0.41) with the effectiveness of rcEPO therapy, as measured by the parameters Keff or AUEC.

Indexed as

Renal DialysisAdultAgedErythrocyte CountErythropoietinFemaleHemoglobinsHumansMaleMiddle AgedRadioimmunoassayRecombinant ProteinsReticulocytesErythropoietinHemoglobinsRecombinant Proteins

Identifiers

PMID1493082
PMCPMC1381451

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.