ArticleBiophysical journal1992
Locomotion forces generated by a polymorphonuclear leukocyte.
Article in Biophysical journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 50 citations in OpenAlex.
- Leukocyte transmigration and longitudinal forward-thrusting force in a microfluidic Transwell device.Biophysical journal · 2021Article
- Biased migration of confined neutrophil-like cells in asymmetric hydraulic environments.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Mechanisms of leading edge protrusion in interstitial migration.Nature communications · 2013Article
- Measurement of the traction force of biological cells by digital holography.Biomedical optics express · 2012Article
- Effects of integrins on laminin chemotaxis by hepatocellular carcinoma cells.Molecular biology reports · 2010Article
- Mathematically modelling the effects of counting factor in Dictyostelium discoideum.Mathematical medicine and biology : a journal of the IMA · 2006Article
- How cellular movement determines the collective force generated by the Dictyostelium discoideum slug.Journal of theoretical biology · 2004Article
- The mechanics of neutrophils: synthetic modeling of three experiments.Biophysical journal · 2003Article
- The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- In vitro characterization and micromechanics of tumor cell chemotactic protrusion, locomotion, and extravasation.Annals of biomedical engineering · 2002Article
- A model for individual and collective cell movement in Dictyostelium discoideum.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Imaging the traction stresses exerted by locomoting cells with the elastic substratum method.Biophysical journal · 1996Article
- Mechanically stimulated cytoskeleton rearrangement and cortical contraction in human neutrophils.Biophysical journal · 1995Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
There have been very few studies which have measured the physical forces generated by cells during active movements. A special micropipette system has been designed to make it possible to observe cell motion within the pipette and to apply a pressure to counter the chemotactic migration of the cell. This provides a direct measure of the locomotion force generated by the cell. The average velocity of forward motion is 0.33 microns/s in the absence of counter-pressure. The application of a positive counter-pressure (C-P) causes a decrease in the velocity of the forward motion of the cell. At 17 cm H2O of C-P, the cell velocity drops to zero and even moves backward with a higher C-P. The results show that the decrement of velocity is linearly related to the magnitude of the C-P with a complete stoppage at a pressure of 17 cm H2O which corresponds to a force of 0.003 dyn. The maximum work rate of the cell is approximately 2.5 x 10(-8) erg/s.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.