ArticleAmerican journal of human genetics2004
Intracranial aneurysms in Finnish families: confirmation of linkage and refinement of the interval to chromosome 19q13.3.
Article in American journal of human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 95 citations in OpenAlex.
- Intracranial Aneurysms: Pathology, Genetics, and Molecular Mechanisms.Neuromolecular medicine · 2019Review
- A Review of the Genetics of Intracranial Berry Aneurysms and Implications for Genetic Counseling.Journal of genetic counseling · 2017Review
- Molecular basis and genetic predisposition to intracranial aneurysm.Annals of medicine · 2014Review
- A balanced translocation truncates Neurotrimin in a family with intracranial and thoracic aortic aneurysm.Journal of medical genetics · 2012Article
- Interactions of miR-34b/c and TP53 polymorphisms on the risk of intracranial aneurysm.Clinical & developmental immunology · 2012Article
- Analysis of positional candidate genes in the AAA1 susceptibility locus for abdominal aortic aneurysms on chromosome 19.BMC medical genetics · 2011Article
- Molecular pathology of aneurysms.Surgical neurology · 2008Article
- Article
- Association analyses confirming a susceptibility locus for intracranial aneurysm at chromosome 14q23.Journal of human genetics · 2008Article
- An investigation of genome-wide associations of hypertension with microsatellite markers in the family blood pressure program (FBPP).Human genetics · 2007Article
- Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms.Human genetics · 2007Article
- A new locus for autosomal dominant intracranial aneurysm, ANIB4, maps to chromosome 5p15.2-14.3.Journal of medical genetics · 2006Article
- The genetics of intracranial aneurysms.Journal of human genetics · 2006Review
- Is there any evidence for linkage on chromosome 17cen in affected Japanese sib-pairs with an intracranial aneurysm?Journal of human genetics · 2006Article
- Mapping a Mendelian form of intracranial aneurysm to 1p34.3-p36.13.American journal of human genetics · 2005Article
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
We recently reported a two-stage genomewide screen of 48 sib pairs affected with intracranial aneurysms (IAs) that revealed suggestive linkage to chromosome 19q13, with a LOD score of 2.58. The region supporting linkage spanned approximately 22 cM. Here, we report a follow-up study of the locus at 19q13, with a sample size expanded to 139 affected sib pairs, along with 83 other affected relative pairs (222 affected relative pairs in total). Suggestive linkage was observed in both independent sample sets, and linkage was significant in the combined set at 70 cM (LOD score 3.50; P=.00006) and at 80 cM (LOD score 3.93; P=.00002). Linkage was highly significant at 70 cM (LOD score 5.70; P=.000001) and at 80 cM (LOD score 3.99; P=.00005) when a covariate measuring the number of affected individuals in the nuclear family was included. To evaluate further the contribution to the linkage signal from families with more than two affected relatives, we performed model-based linkage analysis with a recessive model and a range of penetrances, and we obtained maximum linkage at 70 cM (LOD score 3.16; P=.00007) with a penetrance of 0.3. We then estimated location by using GENEFINDER. The most likely location for a gene predisposing to IAs in the Finnish population is in a region with a 95% confidence interval of 11.6 cM (P=.00007) centered 2.0 cM proximal to D19S246.
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