ArticleNucleic acids research2004
RBD-1, a nucleolar RNA-binding protein, is essential for Caenorhabditis elegans early development through 18S ribosomal RNA processing.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- rRNA intermediates associate with nucleolar reshaping in C. elegans.Nucleic acids research · 2026Article
- Ribosomal protein mutation suppresses gonadal leader cell migration defects in mig-17/ADAMTS mutants in Caenorhabditis elegans.Scientific reports · 2025Article
- A role for BYN-1/bystin in cellular uptake and clearance of residual bodies in the Caenorhabditis elegans germline.Development (Cambridge, England) · 2024Article
- RBM22, a Key Player of Pre-mRNA Splicing and Gene Expression Regulation, Is Altered in Cancer.Cancers · 2022Review
- The ribosomal RNA meLife · 2020Article
- PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans.Nature communications · 2018Article
- Article
- The human WBSCR22 protein is involved in the biogenesis of the 40S ribosomal subunits in mammalian cells.PloS one · 2013Article
- Evolutionary conservation of the ribosomal biogenesis factor Rbm19/Mrd1: implications for function.PloS one · 2012Article
- Nucleologenesis in the Caenorhabditis elegans embryo.PloS one · 2012Article
- The nucleolus of Caenorhabditis elegans.Journal of biomedicine & biotechnology · 2012Review
- A small nucleolar RNA functions in rRNA processing in Caenorhabditis elegans.Nucleic acids research · 2010Article
- RBM19 is essential for preimplantation development in the mouse.BMC developmental biology · 2008Article
- C. elegans nucleostemin is required for larval growth and germline stem cell division.PLoS genetics · 2008Article
- Target of rapamycin (TOR) signaling controls epithelial morphogenesis in the vertebrate intestine.Developmental biology · 2007Article
- RNase MRP and the RNA processing cascade in the eukaryotic ancestor.BMC evolutionary biology · 2007Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
RBD-1 is the Caenorhabditis elegans homolog of Mrd1p, which was recently shown to be required for 18S ribosomal RNA (rRNA) processing in yeast. To gain insights into the relationship between ribosome biogenesis and the development of multicellular organisms, we examined the expression and function of RBD-1. Maternal RBD-1 in the fertilized egg disappears immediately after cleavage starts, whereas zygotic RBD-1 first appears in late embryos and is localized in the nucleolus in most cells, although zygotic transcription of pre-rRNA is known to be initiated as early as the one-cell stage. RNA interference of the rbd-1 gene severely inhibits the processing of 18S rRNA in association with various developmental abnormalities, indicating its essential role in pre-rRNA processing and development in C.elegans. These results provide evidence for the linkage between ribosome biogenesis and the control of development and imply unexpected uncoupling of transcription and processing of pre-rRNA in early C.elegans embryos.
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