Evidence map›Paper›PMID 14871954›Full record

ArticleEukaryotic cell2004

SmD1 is required for spliced leader RNA biogenesis.

Gusti M Zeiner, Silvie Foldynová, Nancy R Sturm, Julius Lukes, David A Campbell

Open access · diamondAbstract read
In one paragraph

Article in Eukaryotic cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

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  13. Spliced leader RNA trans-splicing in dinoflagellates.Proceedings of the National Academy of Sciences of the United States of America · 2007
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Gusti M ZeinerDepartment of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095-1489, USA.
Silvie Foldynová
Nancy R Sturm
Julius Lukes
David A Campbell
University of California, Los Angeles · USCzech Academy of Sciences · CZ

Funding

MULTIDISCIPLINARY TRAINING IN MICROBIAL PATHOGENESIST32AI007323 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peter John Bradley · 1988 to 2026
$8.6M
EXPRESSION OF THE LEISHMANIA TARENTOLAE SL RNA GENER01AI034536 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAMPBELL, DAVID A · 1995 to 2003
$1.0M
Adaptation of ribozyme technology to LeishmaniaR03AI054496 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI STURM, NANCY R · 2003 to 2004
$153k
NIAID NIH HHS 2-T32-AI-07323NIAID NIH HHS AI054496NIAID NIH HHS AI34536NIAID NIH HHS R01 AI034536NIAID NIH HHS R03 AI054496NIAID NIH HHS T32 AI007323
6 · The paper itself

Abstract

The Sm-binding site of the kinetoplastid spliced leader RNA has been implicated in accurate spliced leader RNA maturation and trans-splicing competence. In Trypanosoma brucei, RNA interference-mediated knockdown of SmD1 caused defects in spliced leader RNA maturation, displaying aberrant 3'-end formation, partial formation of cap 4, and overaccumulation in the cytoplasm; U28 pseudouridylation was unaffected.

Indexed as

Alternative SplicingAnimalsBinding SitesCytoplasmDNA, KinetoplastExonsMutationPhenotypeProtein BindingPseudouridineRibonucleoproteins, Small NuclearRNARNA InterferenceRNA, MessengerRNA Processing, Post-TranscriptionalRNA, Spliced LeaderDNA, KinetoplastPseudouridineRibonucleoproteins, Small NuclearRNARNA, MessengerRNA, Spliced Leader

Identifiers

PMID14871954
PMCPMC329508
OpenAlexW2074341138

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.