ArticleKidney international2004
Effects of AT1 receptor blockade on renal injury and mitogen-activated protein activity in Dahl salt-sensitive rats.
Article in Kidney international, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 90 citations in OpenAlex.
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- Alleviation of salt-induced exacerbation of cardiac, renal, and visceral fat pathology in rats with metabolic syndrome by surgical removal of subcutaneous fat.Nutrition & diabetes · 2020Article
- Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent.Scientific reports · 2020Article
- Time Course Changes in Urinary Angiotensinogen and Circulating N-Terminal Pro-B-Type Natriuretic Peptide in Patients Hospitalized with Acute Heart Failure.Internal medicine (Tokyo, Japan) · 2020Article
- Transcription Factor ETS-1 and Reactive Oxygen Species: Role in Vascular and Renal Injury.Antioxidants (Basel, Switzerland) · 2018Review
- Skeletal muscle insulin resistance in salt-sensitive hypertension: role of angiotensin II activation of NFκB.Cardiovascular diabetology · 2015Article
- Disturbed circadian rhythm of the intrarenal renin-angiotensin system: relevant to nocturnal hypertension and renal damage.Clinical and experimental nephrology · 2015Article
- Transcription factor avian erythroblastosis virus E26 oncogen homolog-1 is a novel mediator of renal injury in salt-sensitive hypertension.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Renal tubule angiotensin II type 1 receptor-associated protein promotes natriuresis and inhibits salt-sensitive blood pressure elevation.Journal of the American Heart Association · 2015Article
- Article
- Angiotensin II regulates ACE and ACE2 in neurons through p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2 signaling.American journal of physiology. Cell physiology · 2013Article
- Renoprotective effects of telmisartan after unilateral renal ablation in rats.International journal of nephrology and renovascular disease · 2013Article
- Angiotensin II blockade and renal protection.Current pharmaceutical design · 2013Review
- Angiotensin-converting enzyme inhibitor does not suppress renal angiotensin II levels in angiotensin I-infused rats.Journal of pharmacological sciences · 2013Article
- Nuclear hormone receptors in podocytes.Cell & bioscience · 2012Article
- Liver angiotensinogen is the primary source of renal angiotensin II.Journal of the American Society of Nephrology : JASN · 2012Article
- Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat.Journal of cardiovascular pharmacology · 2012Article
- Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system.Circulation research · 2012Review
- Renal sympathetic denervation suppresses de novo podocyte injury and albuminuria in rats with aortic regurgitation.Circulation · 2012Article
- Relationship between urinary angiotensinogen and salt sensitivity of blood pressure in patients with IgA nephropathy.Hypertension (Dallas, Tex. : 1979) · 2011Article
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe mitogen-activated protein kinase (MAPK) cascade is an important intracellular mediator of angiotensin II (Ang II)-induced cell growth and differentiation. Here, we examined the effect of angiotensin II type 1 receptor (AT1) receptor blockade on renal injury and MAPK activity in Dahl salt-sensitive (DS) rats.
methodsDS rats were maintained on a high (H: 8.0%NaCl, N= 8) or low (L: 0.3%NaCl, N= 7) salt diet, or H + candesartan cilexetil (10 to 15 mg/kg/day, N= 8). Urinary protein excretion (UproteinV), renal cortical collagen content, and glomerular injury (assessed by semiquantitative morphometric analysis) were determined after 4-week treatments. Plasma and kidney Ang II levels were measured by radioimmunoassay. Protein levels of AT1 and AT2 receptors in the renal cortical tissues were analyzed by Western-blotting analyses. MAPKs activities, including extracellular signal-regulated kinases (ERK)1/2, c-Jun NH2-terminal kinases (JNK), p38 MAPK, and Big-MAPK-1 (BMK1), were measured by Western-blotting analyses or in vitro kinase assays.
resultsDS/H rats showed higher mean blood pressure (MBP), UproteinV, and renal cortical collagen content than DS/L rats. Increased ERK1/2, JNK, and BMK1 activities were observed in renal cortical tissues of DS/H rats (approximately 6.3-, 4.5-, and 2.5-fold, respectively), whereas p38 MAPK activity was unchanged. Plasma Ang II levels were significantly reduced in DS/H rats compared with DS/L rats, whereas kidney Ang II contents and AT1 receptor protein levels were similar. Candesartan did not alter MBP, but significantly reduced UproteinV and collagen content, and ameliorated progressive sclerotic and proliferative glomerular changes. Furthermore, candesartan decreased renal tissue Ang II contents (from 216 +/- 19 to 46 +/- 3 fmol/mL) and ERK1/2, JNK, and BMK1 activities (-45%, -60%, and -70%, respectively) in DS/H rats.
conclusionIn DS hypertensive rats, some of the renoprotective effects of AT1 receptor blockade are accompanied by reductions in intrarenal Ang II contents and MAPK activity, which might not be mediated through arterial pressure changes.
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