ReviewCell proliferation2004
The gastrointestinal stem cell.
Review in Cell proliferation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 66 citations in OpenAlex.
- Colorectal cancer in south sulawesi: a case-control study for nongenetic risk factors.Oncology reviews · 2025Article
- A comparison of epigenetic mitotic-like clocks for cancer risk prediction.Genome medicine · 2020Article
- Epithelial-Mesenchymal Interactions for the Development of Intestinal Villi.Development & reproduction · 2019Article
- Delivery of Mesenchymal Stem Cells from Gelatin-Alginate Hydrogels to Stomach Lumen for Treatment of Gastroparesis.Bioengineering (Basel, Switzerland) · 2018Article
- Article
- Gastric carcinogenesis.World journal of gastroenterology · 2012Article
- CD24 can be used to isolate Lgr5+ putative colonic epithelial stem cells in mice.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Different modes of renal proximal tubule regeneration in health and disease.World journal of nephrology · 2012Article
- Therapeutic application of stem cells in gastroenterology: an up-date.World journal of gastroenterology · 2011Review
- The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach; particularly increasing in mucosae of Helicobacter-associated gastritis.Journal of gastroenterology · 2011Article
- Critical appraisal of ex vivo expansion of human limbal epithelial stem cells.Current molecular medicine · 2010Review
- Therapeutic implications of colon cancer stem cells.World journal of gastroenterology · 2010Review
- Colonic stem cell data are consistent with the immortal model of stem cell division under non-random strand segregation.Cell proliferation · 2009Article
- Urothelial progenitor cells: regional differences in the rat bladder.Cell proliferation · 2007Article
- An enteroendocrine cell-based model for a quiescent intestinal stem cell niche.Cell proliferation · 2006Article
- Epimorphin(-/-) mice have increased intestinal growth, decreased susceptibility to dextran sodium sulfate colitis, and impaired spermatogenesis.The Journal of clinical investigation · 2006Article
- The gastrointestinal tract stem cell niche.Stem cell reviews · 2006Review
- Intrarenal cells, not bone marrow-derived cells, are the major source for regeneration in postischemic kidney.The Journal of clinical investigation · 2005Article
- Stem cells and colorectal carcinogenesis.Journal of medicine and lifeReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The longevity of adult stem cells, and their potential for vast tissue regeneration, makes them a focal point of current research and debate, with future aspirations for the use of stem cells in the treatment of a number of human pathological conditions. Due to the rapid rate of cell turnover in the gastrointestinal tract, the stem cells of this tissue are amongst the most assiduous in the body, although they remain unidentified to this day due to their immature, undifferentiated phenotype. However, our knowledge of the mechanisms regulating gastrointestinal stem cell function is evolving, with the identification of putative cellular markers and the elucidation of signalling pathways which regulate cell behaviour in the normal and neoplastic gastrointestinal tract. This review describes the fundamental properties of the gastrointestinal stem cell including: (i) their number, location and origins, (ii) their primary function of deriving gastrointestinal cell lineages and maintaining tissue homeostasis, (iii) the acquisition of gastrointestinal cell lineages from adult stem cells of extraneous tissues and the consequences of this in a therapeutic context, and (iv) the genetic and morphological phenomena surrounding neoplastic transformation in the gastrointestinal tract.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.