ReviewCell proliferation2004
Hepatic stem cells: from inside and outside the liver?
Review in Cell proliferation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 148 citations in OpenAlex.
- Functional characterization of CD49fJournal of molecular histology · 2022Article
- The Cancer Stem Cell in Hepatocellular Carcinoma.Cancers · 2020Review
- Circulating CD34+ hematopoietic stem/progenitor cells paralleled with level of viremia in patients chronically infected with hepatitis B virus.Regenerative medicine research · 2018Article
- Generation of functional hepatocyte-like cells from human deciduous periodontal ligament stem cells.Die Naturwissenschaften · 2016Article
- Cancer Stem Cell and Gastrointestinal Cancer: Current Status, Targeted Therapy and Future Implications.Biochemistry & pharmacology : open access · 2016Article
- Identification and characterization of mesenchymal-epithelial progenitor-like cells in normal and injured rat liver.The American journal of pathology · 2015Article
- Stem cells in gastrointestinal cancers: The road less travelled.World journal of stem cells · 2014Review
- Adult hepatocytes are generated by self-duplication rather than stem cell differentiation.Cell stem cell · 2014Article
- Hepatic progenitor cells in canine and feline medicine: potential for regenerative strategies.BMC veterinary research · 2014Review
- Human bone marrow mesenchymal stem cell-derived hepatocytes improve the mouse liver after acute acetaminophen intoxication by preventing progress of injury.International journal of molecular sciences · 2014Article
- Complement 5a stimulates hepatic stellate cells in vitro, and is increased in the plasma of patients with chronic hepatitis B.Immunology · 2013Article
- Partial hepatectomy in rats results in immediate down-regulation of p27Kip1 in residual liver tissue by transcriptional and post-translational processes.Frontiers in physiology · 2013Article
- Liver fibrosis: mechanisms of immune-mediated liver injury.Cellular & molecular immunology · 2012Review
- Differentiation of bone marrow-derived mesenchymal stem cells into hepatocyte-like cells on nanofibers and their transplantation into a carbon tetrachloride-induced liver fibrosis model.Stem cell reviews and reports · 2011Article
- Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Regeneration of multilineage skin epithelia by differentiated keratinocytes.The Journal of investigative dermatology · 2010Article
- Intestinal metaplasia in liver of rats after partial hepatectomy and treatment with acetylaminofluorene.Cell proliferation · 2009Article
- Gallbladder epithelial cells that engraft in mouse liver can differentiate into hepatocyte-like cells.The American journal of pathology · 2009Article
- Stem cells for end stage liver disease: how far have we got?World journal of gastroenterology · 2008Review
- Stage-specific regulation of adhesion molecule expression segregates epithelial stem/progenitor cells in fetal and adult human livers.Hepatology international · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The liver is normally proliferatively quiescent, but hepatocyte loss through partial hepatectomy, uncomplicated by virus infection or inflammation, invokes a rapid regenerative response from all cell types in the liver to perfectly restore liver mass. Moreover, hepatocyte transplants in animals have shown that a certain proportion of hepatocytes in foetal and adult liver can clonally expand, suggesting that hepatoblasts/hepatocytes are themselves the functional stem cells of the liver. More severe liver injury can activate a potential stem cell compartment located within the intrahepatic biliary tree, giving rise to cords of bipotential transit amplifying cells (oval cells), that can ultimately differentiate into hepatocytes and biliary epithelial cells. A third population of stem cells with hepatic potential resides in the bone marrow; these haematopoietic stem cells may contribute to the albeit low renewal rate of hepatocytes, but can make a more significant contribution to regeneration under a very strong positive selection pressure. In such instances, cell fusion rather than transdifferentiation appears to be the underlying mechanism by which the haematopoietic genome becomes reprogrammed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.