ArticleExperimental brain research1992
Kindling is associated with the formation of novel mossy fibre synapses in the CA3 region.
Article in Experimental brain research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 137 citations in OpenAlex.
- Article
- Expansion of the dentate mossy fiber-CA3 projection in the brain-derived neurotrophic factor-enriched mouse hippocampus.Neuroscience · 2015Article
- Homeostatic regulation of NCAM polysialylation is critical for correct synaptic targeting.Cellular and molecular life sciences : CMLS · 2012Article
- Development of later life spontaneous seizures in a rodent model of hypoxia-induced neonatal seizures.Epilepsia · 2011Article
- Adult hippocampal neurogenesis and plasticity in the infrapyramidal bundle of the mossy fiber projection: I. Co-regulation by activity.Frontiers in neuroscience · 2011Article
- Structural plasticity of dentate granule cell mossy fibers during the development of limbic epilepsy.Hippocampus · 2010Article
- Differential effects of AMPA receptor activation on survival and neurite integrity during neuronal development.Molecular and cellular neurosciences · 2007Article
- Repair of the injured adult hippocampus through graft-mediated modulation of the plasticity of the dentate gyrus in a rat model of temporal lobe epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Increased expression of brain-derived neurotrophic factor induces formation of basal dendrites and axonal branching in dentate granule cells in hippocampal explant cultures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Seizure-Induced Axonal Sprouting: Assessing Connections Between Injury, Local Circuits, and Epileptogenesis.Epilepsy currents · 2002Article
- Cyclic nucleotide-mediated regulation of hippocampal mossy fiber development: a target-specific guidance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Expression of synaptopodin, an actin-associated protein, in the rat hippocampus after limbic epilepsy.Brain pathology (Zurich, Switzerland) · 2001Article
- Nerve growth factor accelerates seizure development, enhances mossy fiber sprouting, and attenuates seizure-induced decreases in neuronal density in the kindling model of epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- A nerve growth factor peptide retards seizure development and inhibits neuronal sprouting in a rat model of epilepsy.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- The influence of diazepam on learning processes impaired by pentylenetetrazol kindling.Naunyn-Schmiedeberg's archives of pharmacology · 1994Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A Golgi and electron microscopy study of the hippocampal CA3 region was performed on control and kindled Wistar rats. The observations provide evidence that, in epileptic rats, mossy fibres sprout and establish novel synapses with the basilar dendrites of CA3 pyramidal neurons. These newly-developed synapses showed the typical features of mossy synapses observed in the stratum lucidum, including the appearance of complex giant spines. The morphological changes reported here may represent a histopathological substrate for the epilepsy in the absence of overt signs of a hippocampal lesion.
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