ArticleEnvironmental health perspectives1992
The human glutathione S-transferase supergene family, its polymorphism, and its effects on susceptibility to lung cancer.
Article in Environmental health perspectives, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 213 citations in OpenAlex.
- GSTM1 polymorphism and lung cancer risk among East Asian populations: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Glutathione S-transferase M1 null genotype meta-analysis on gastric cancer risk.Diagnostic pathology · 2014Pooled it
- Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: a HuGE-GSEC review.American journal of epidemiology · 2009Pooled it
- Five glutathione s-transferase gene variants in 23,452 cases of lung cancer and 30,397 controls: meta-analysis of 130 studies.PLoS medicine · 2006Pooled it
- Association of GSTM1, GSTT1, and GSTP1 Gene Polymorphisms With Susceptibility to Periodontitis: A Systematic Review and Meta-Analysis With Exploratory Analysis of Apical Periodontitis.International journal of dentistry · 2026Review
- Glutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study.BMC oral health · 2024Article
- The Relation between Polymorphisms in Exon 5 and Exon 6 of GSTP1 Gene and the Risk of Lung Cancer in Iranian PeopleAsian Pacific journal of cancer prevention : APJCP · 2019Article
- GSTM1 and GSTT1 Genetic Polymorphisms and Breast Cancer Risk in Selected Filipino CasesAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Combined Genetic Biomarkers Confer Susceptibility to Risk of Urothelial Bladder Carcinoma in a Saudi Population.Disease markers · 2017Article
- Polycyclic aromatic hydrocarbons: from metabolism to lung cancer.Toxicological sciences : an official journal of the Society of Toxicology · 2015Review
- [Molecular epidemiology study in Xuanwei: the relationship among coal type, genotype and lung cancer risk].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2015Article
- Association of GSTT1 and GSTM1 polymorphisms with blood pressure: A Bayesian modeling of continuous data.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Article
- Novel study on N-nitrosamines as risk factors of cardiovascular diseases.BioMed research international · 2014Article
- Antioxidant status and GST gene polymorphisms in antitubercular treatment-induced hepatotoxicity patients.Hepatology international · 2013Article
- Genetic susceptibility to lung cancer--light at the end of the tunnel?Carcinogenesis · 2013Review
- Distinct SNP combinations confer susceptibility to urinary bladder cancer in smokers and non-smokers.PloS one · 2012Article
- Role of genetic changes in the progression of cardiovascular diseases.International journal of biomedical science : IJBS · 2011Article
- Reactive oxygen species, anti-oxidant enzymes and smoldering chronic inflammation: Relevance to diabetes mellitus, atherosclerosis, and menopausal metabolic syndrome.Journal of mid-life health · 2011Article
- Multiple analytical approaches reveal distinct gene-environment interactions in smokers and non smokers in lung cancer.PloS one · 2011Article
- Polymorphisms of CYP1A1, GSTM1 and GSTT1 Loci as the Genetic Predispositions of Oral Cancers and Other Oral Pathologies: Tobacco and Alcohol as Risk Modifiers.Indian journal of clinical biochemistry : IJCB · 2010Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytosolic glutathione S-transferases (GSTs) are a supergene family of dimeric enzymes capable of detoxifying a number of carcinogenic electrophiles. Of the numerous components of tobacco smoke, the polycyclic aromatic hydrocarbons appear to be the principal compounds that yield substrates for these enzymes, GSTM1-1 being effective with those PAH derivatives so far studied; however, the gene locus for GSTM1 is polymorphic, containing two well-characterized expressing genes and a null allele. Use of cDNA for GSTM1-1 or appropriate fragments of genomic clones as probes in Southern blots indicated that the null allele is due to the absence of GSTM1. In preliminary experiments, described here, with lung tissue from smokers, levels of 32P-postlabeled nuclease P1-enhanced DNA adducts were inversely correlated with levels of antigen cross-reacting with antibody to GSTM1-1, suggesting that initiation depends on the expression of GSTM1-1. Since similar quantities of DNA adducts and GSTM1-1 activity have been shown to occur in bronchial and peripheral lung, however, the development of malignancy, which is usually in the bronchial region, presumably depends on additional factors that bring about promotion and progression, which are not necessarily affected by GSTM1 expression. Two epidemiological studies have been carried out in which a possible correlation between the absence of GSTM1 and lung cancer incidence is considered. In the first, involving a U.S. population sample, smokers with and without lung cancer were phenotyped, and a highly significant correlation between the absence of GSTM1-1 activity and adenocarcinoma of the lung was observed.(ABSTRACT TRUNCATED AT 250 WORDS)
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